Oncogene elements within an endogenous retrovirus.

K. A. Whartenby, R. A. Insel, S. M. Freeman, P. Keng, G. N. Abraham

Research output: Contribution to journalArticlepeer-review

Abstract

The human genome contains a large number of endogenous retroviral-related sequences. While the function of these sequences is unknown, they may contribute to disease processes through their regions of homology with infectious retroviruses. We have been further characterizing a recently reported HTLV-1 related endogenous retroviral sequence cloned from T lymphocytes isolated from a patient with essential cryoglobulinemia. We here report further detailed transcriptional analysis of the sequence for tissue and cell-cycle specificity and a novel finding of an association between the endogenous retrovirus and a ras-related gene.

Original languageEnglish (US)
Pages (from-to)113-122
Number of pages10
JournalActa virologica
Volume37
Issue number2-3
StatePublished - 1993

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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