@article{66d4bcfc34f34c0bb32a26badc599bc4,
title = "Once-daily versus Twice-daily Levobunolol (0.5%) Therapy: A Crossover Study",
abstract = "The authors executed a two-period, randomized, double-masked, crossover study comparing once-daily to twice-daily levobunolol hydrochloride (0.5%) in 20 patients with elevated intraocular pressure (10P). Modified diurnal curves were performed at four times for each study arm: baseline, day 1, day 14, and day 28. The mean diurnal corrected decrease in 10P from baseline ranged from 16% ± 11 % to 22% ± 9% when the subjects were treated twice daily, and from 14% ± 10% to 18% ± 8% when the same subjects were treated once daily. At day 1, patients had a significantly greater 101? lowering after twice-daily therapy than after once-daily therapy (P < 0.05). At 14 and 28 days, there was no clinically significant difference between the two treatment regimens. The results of our crossover study suggest that once-daily treatment with levobunolol (0.5%) is as effective as twice-daily treatment.",
author = "Derick, {Robert J.} and Robin, {Alan L.} and James Tielsch and Wexler, {Jeffrey L.} and Kelley, {Elaine P.} and Stoecker, {Jack F.} and Novack, {Gary D.} and Coleman, {Anne L.}",
note = "Funding Information: Originally received: July 25. 1991. Revision accepted: October 22. 1991. I Glaucoma Service. Wilmer Institute. Johns Hopkins Hospital. Baltimore. 2 Krieger Eye Institute. Sinai Hospital, Baltimore. 3 Dana Center. Wilmer Institute, Johns Hopkins Hospital. Baltimore. 4AIlergan Pharmaceuticals, Irvine. Presented in part at the Association for Research in Vision and Ophthalmology Annual Meeting, Sarasota. April 1990. Supported in part by a grant from the Zanvyl Krieger Foundation and Allergan. Inc. Irvine. California. Dr. Coleman is currently affiliated with the Department of Ophthalmology. UCLA School of Medicine. Los Angeles. Dr. Novack is currently affiliated with Pharmalogic, Inc. Irvine. Drs. Derick. Rohin. Tielsch. Wexler. and Coleman have no proprietary interests in Allergan. Inc, or levobunolol. Reprint requests to Alan 1.. Robin. MD. 6115 Falls Rd. Third Floor, Baltimore. MD 21209-2226.",
year = "1992",
doi = "10.1016/S0161-6420(92)31957-8",
language = "English (US)",
volume = "99",
pages = "424--429",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "3",
}