On water: Catalyst-free chemoselective synthesis of highly functionalized tetrahydroquinazolines from 2-aminophenylacrylate

Rakesh K. Saunthwal, Monika Patel, Rakesh K. Tiwari, Keykavous Parang, Akhilesh K. Verma

Research output: Contribution to journalArticle

Abstract

A green and catalyst-free atom-ecomonic straightforward tandem approach for the synthesis of highly functionalized tetrahydroquinazolines by the reaction of 2-aminophenylacrylates with isothiocyanates using water as an environmentally friendly solvent via amidation and concomitant chemoselective Michael-addition is described. This journal is

Original languageEnglish (US)
Pages (from-to)1434-1441
Number of pages8
JournalGreen Chemistry
Volume17
Issue number3
DOIs
StatePublished - Mar 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution

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