On the use of the quasi-likelihood method in teratological experiments

K. Y. Liang, J. Hanfell

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


This paper concerns the impact of litter effects on the inference of dose- response relationships in teratological experiments with binary response. Kupper et al. (1986, Biometrics 42, 85-98) concluded that when intra-litter correlations are dose-dependent, the use of a common intra-litter correlation likelihood based on the beta-binomial distribution could lead to severe bias in estimation of the parameter β, which characterizes the dose-response relationship. We show here that the problems of bias and coverage probability for β could still be substantial when one uses the likelihood with heterogeneous intra-litter correlations. We then examine through a simulation study the performance of the quasi-likelihood method (Wedderburn, 1974, Biometrika 61, 439-447) and recommend that this method with a common intra- litter correlation parameter be used when the number of litters is small or modest.

Original languageEnglish (US)
Pages (from-to)872-880
Number of pages9
Issue number3
StatePublished - 1994

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics


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