Abstract
This paper concerns the impact of litter effects on the inference of dose- response relationships in teratological experiments with binary response. Kupper et al. (1986, Biometrics 42, 85-98) concluded that when intra-litter correlations are dose-dependent, the use of a common intra-litter correlation likelihood based on the beta-binomial distribution could lead to severe bias in estimation of the parameter β, which characterizes the dose-response relationship. We show here that the problems of bias and coverage probability for β could still be substantial when one uses the likelihood with heterogeneous intra-litter correlations. We then examine through a simulation study the performance of the quasi-likelihood method (Wedderburn, 1974, Biometrika 61, 439-447) and recommend that this method with a common intra- litter correlation parameter be used when the number of litters is small or modest.
Original language | English (US) |
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Pages (from-to) | 872-880 |
Number of pages | 9 |
Journal | Biometrics |
Volume | 50 |
Issue number | 3 |
DOIs | |
State | Published - 1994 |
Externally published | Yes |
ASJC Scopus subject areas
- Statistics and Probability
- General Biochemistry, Genetics and Molecular Biology
- General Immunology and Microbiology
- General Agricultural and Biological Sciences
- Applied Mathematics