@article{6495480083d0436ebe431f687369f61b,
title = "On the slope of the regression between stem cell divisions and cancer risk, and the lack of correlation between stem cell divisions and environmental factors-associated cancer risk",
abstract = "We are pleased that the analyses on smoking and radiation performed by Little et al. support the idea that the effects of various environmental factors on cancer risk do not correlate significantly with the lifetime number of stem cell divisions. This provides further evidence that the correlation we obtained for the U.S., and similarly found across the rest of the world, is in general not due to environmental factors but rather is due to intrinsic ones. We also point out mathematical and conceptual mistakes in the analysis of Little et al. that led them to erroneous conclusions.",
author = "Cristian Tomasetti and Bert Vogelstein",
note = "Funding Information: This work was supported by The John Templeton Foundation, The Virginia and D.K. Ludwig Fund for Cancer Research, The Lustgarten Foundation for Pancreatic Cancer Research, The Sol Goldman Center for Pancreatic Cancer Research, and NIH Grants P30-CA006973, R37-CA43460, RO1-CA57345, and P50-CA62924. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2017 Tomasetti, Vogelstein. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2017",
month = may,
doi = "10.1371/journal.pone.0175535",
language = "English (US)",
volume = "12",
journal = "PloS one",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",
}