On the sensitivity of ASL MRI in detecting regional differences in cerebral blood flow

Sina Aslan, Hanzhang Lu

Research output: Contribution to journalArticle

Abstract

Arterial-spin-labeling (ASL) magnetic resonance imaging (MRI) provides a noninvasive tool to measure cerebral blood flow (CBF) and is increasingly used as a surrogate for baseline neural activity. However, the power of ASL MRI in detecting CBF differences between patient and control subjects is hampered by inter-subject variations in global CBF, which are associated with non-neural factors and may contribute to the noise in the across-group comparison. Here, we investigated the sensitivity of this technique and proposed a normalization strategy to better detect such a difference. A "model" situation was employed in which two visual stimuli (i.e. cross fixation and flashing checkerboard) were presented to two groups of subjects to mimic "control" and "patient" groups (N=7 for each group), respectively. It was found that absolute CBF (aCBF) in the occipital lobe in the checkerboard group was 26.0% greater compared to the fixation group, but the level of significance was modest (P= 03). In contrast, when normalizing the CBF with whole-brain CBF or CBF in a reference region [termed relative CBF (rCBF)], the statistical significance was improved considerably (P

Original languageEnglish (US)
Pages (from-to)928-935
Number of pages8
JournalMagnetic Resonance Imaging
Volume28
Issue number7
DOIs
StatePublished - Sep 2010
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Magnetic resonance
Labeling
Blood
Magnetic Resonance Imaging
Imaging techniques
Occipital Lobe
Noise
Brain

Keywords

  • ASL MRI
  • Cerebral blood flow
  • Group analysis
  • PCASL
  • Perfusion
  • Sensitivity

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Biomedical Engineering

Cite this

On the sensitivity of ASL MRI in detecting regional differences in cerebral blood flow. / Aslan, Sina; Lu, Hanzhang.

In: Magnetic Resonance Imaging, Vol. 28, No. 7, 09.2010, p. 928-935.

Research output: Contribution to journalArticle

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