On the role of p53 in the cellular response to aneuploidy

Akshay Narkar; Blake A. Johnson; Pandurang Bharne; Jin Zhu; Veena Padmanaban; Debojyoti Biswas; Andrew Fraser; Pablo A. Iglesias; Andrew J. Ewald; Rong Li

doi:10.1016/j.celrep.2021.108892

On the role of p53 in the cellular response to aneuploidy

Akshay Narkar, Blake A. Johnson, Pandurang Bharne, Jin Zhu, Veena Padmanaban, Debojyoti Biswas, Andrew Fraser, Pablo A. Iglesias, Andrew J. Ewald, Rong Li

Research output: Contribution to journal › Article › peer-review

Abstract

By investigating how various cell lines and organotypic cultures respond to the induction of aneuploidy, Narkar et al. show that p53 does not constitute a universal surveillance mechanism against aneuploidy. p53 prevents aneuploidy by limiting mitotic errors in colon organoids.

Original language	English (US)
Article number	108892
Journal	Cell Reports
Volume	34
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2021.108892
State	Published - Mar 23 2021

Keywords

G1 arrest
aneuploidy
mitosis
organoids
p53

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2021.108892

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abstract = "By investigating how various cell lines and organotypic cultures respond to the induction of aneuploidy, Narkar et al. show that p53 does not constitute a universal surveillance mechanism against aneuploidy. p53 prevents aneuploidy by limiting mitotic errors in colon organoids.",

keywords = "G1 arrest, aneuploidy, mitosis, organoids, p53",

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AU - Narkar, Akshay

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AU - Zhu, Jin

AU - Padmanaban, Veena

AU - Biswas, Debojyoti

AU - Fraser, Andrew

AU - Iglesias, Pablo A.

AU - Ewald, Andrew J.

AU - Li, Rong

PY - 2021/3/23

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KW - aneuploidy

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KW - organoids

KW - p53

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On the role of p53 in the cellular response to aneuploidy

Abstract

Keywords

ASJC Scopus subject areas

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