On the Probability of Random Genetic Mutations for Various Types of Tumor Growth

Research output: Contribution to journalArticlepeer-review

Abstract

In this work, we consider the problem of estimating the probability for a specific random genetic mutation to be present in a tumor of a given size. Previous mathematical models have been based on stochastic methods where the tumor was assumed to be homogeneous and, on average, growing exponentially. In contrast, we are able to obtain analytical results for cases where the exponential growth of cancer has been replaced by other, arguably more realistic types of growth of a heterogeneous tumor cell population. Our main result is that the probability that a given random mutation will be present by the time a tumor reaches a certain size, is independent of the type of curve assumed for the average growth of the tumor, at least for a general class of growth curves. The same is true for the related estimate of the expected number of mutants present in a tumor of a given size, if mutants are indeed present.

Original languageEnglish (US)
Pages (from-to)1379-1395
Number of pages17
JournalBulletin of Mathematical Biology
Volume74
Issue number6
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Keywords

  • Branching processes
  • Drug resistance
  • Genetic mutations
  • Ordinary differential equations
  • Stem cells
  • Tumor growth

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Mathematics(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Pharmacology
  • Agricultural and Biological Sciences(all)
  • Computational Theory and Mathematics

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