On the prevention and analysis of missing data in randomized clinical trials: The state of the art

Daniel O. Scharfstein, Joseph Hogan, Amir Herman

Research output: Contribution to journalShort surveypeer-review

Abstract

We summarize and elaborate on the recently published National Research Council report entitled "The Prevention and Treatment of Missing Data in Clinical Trials." We tailor our discussion to orthopaedic trials. In particular, we discuss the intent-to-treat principle, review study design and prevention ideas to minimize missing data, and present state-of-the-art sensitivity analysis methods for analyzing and reporting the results of studies with missing data.

Original languageEnglish (US)
Pages (from-to)80-84
Number of pages5
JournalJournal of Bone and Joint Surgery - Series A
Volume94
Issue numberSUPPL. 1
DOIs
StatePublished - Jul 18 2012

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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