TY - JOUR
T1 - On the origin of event-related potentials indexing covert attentional selection during visual search
AU - Cohen, Jeremiah Y.
AU - Heitz, Richard P.
AU - Schall, Jeffrey D.
AU - Woodman, Geoffrey F.
PY - 2009/10
Y1 - 2009/10
N2 - Despite nearly a century of electrophysiological studies recording extracranially from humans and intracranially from monkeys, the neural generators of nearly all human event-related potentials (ERPs) have not been definitively localized. We recorded an attention-related ERP component, known as the N2pc, simultaneously with intracranial spikes and local field potentials (LFPs) in macaques to test the hypothesis that an attentional-control structure, the frontal eye field (FEF), contributed to the generation of the macaque homologue of the N2pc (m-N2pc). While macaques performed a difficult visual search task, the search target was selected earliest by spikes from single FEF neurons, later by FEF LFPs, and latest by the m-N2pc. This neurochronometric comparison provides an empirical bridge connecting macaque and human experiments and a step toward localizing the neural generator of this important attention-related ERP component.
AB - Despite nearly a century of electrophysiological studies recording extracranially from humans and intracranially from monkeys, the neural generators of nearly all human event-related potentials (ERPs) have not been definitively localized. We recorded an attention-related ERP component, known as the N2pc, simultaneously with intracranial spikes and local field potentials (LFPs) in macaques to test the hypothesis that an attentional-control structure, the frontal eye field (FEF), contributed to the generation of the macaque homologue of the N2pc (m-N2pc). While macaques performed a difficult visual search task, the search target was selected earliest by spikes from single FEF neurons, later by FEF LFPs, and latest by the m-N2pc. This neurochronometric comparison provides an empirical bridge connecting macaque and human experiments and a step toward localizing the neural generator of this important attention-related ERP component.
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U2 - 10.1152/jn.00680.2009
DO - 10.1152/jn.00680.2009
M3 - Article
C2 - 19675287
AN - SCOPUS:70350333559
SN - 0022-3077
VL - 102
SP - 2375
EP - 2386
JO - Journal of neurophysiology
JF - Journal of neurophysiology
IS - 4
ER -