TY - JOUR
T1 - On the nested hierarchical organization of CNS
T2 - Basic characteristics of neuronal molecular networks
AU - Agnati, Luigi Francesco
AU - Santarossa, Letizia
AU - Genedani, Susanna
AU - Canela, Enric I.
AU - Leo, Giuseppina
AU - Franco, Rafael
AU - Woods, Amina
AU - Lluis, Carmen
AU - Ferré, Sergi
AU - Fuxe, Kjell
PY - 2004
Y1 - 2004
N2 - It has been suggested that the Central Nervous System (CNS) is built as a "nested system of networks of networks" structured according to hierarchical principles. Thus, it is possible to recognize networks at multiple scales (miniaturisation principle) moving top-down from neuronal to molecular networks. Such a nested organization of the CNS leads to the problem how circulation and integration of information at different levels of miniaturisation (i.e., macro-scale, meso-scale and micro-scale) take place. We suggest that local circuits are the highly specialised meso-scale level capable of functionally interconnecting macrowith micro-scale level. Furthermore, it is suggested that the same modes for communication (Wiring and Volume Transmission) are in operation at various miniaturisation levels. This indicates a sort of "fractal organization" of the CNS. Detailed analysis of molecular networks is discussed. In particular, receptor-receptor interactions are examined as an important input to horizontal molecular networks located at plasma membrane level.
AB - It has been suggested that the Central Nervous System (CNS) is built as a "nested system of networks of networks" structured according to hierarchical principles. Thus, it is possible to recognize networks at multiple scales (miniaturisation principle) moving top-down from neuronal to molecular networks. Such a nested organization of the CNS leads to the problem how circulation and integration of information at different levels of miniaturisation (i.e., macro-scale, meso-scale and micro-scale) take place. We suggest that local circuits are the highly specialised meso-scale level capable of functionally interconnecting macrowith micro-scale level. Furthermore, it is suggested that the same modes for communication (Wiring and Volume Transmission) are in operation at various miniaturisation levels. This indicates a sort of "fractal organization" of the CNS. Detailed analysis of molecular networks is discussed. In particular, receptor-receptor interactions are examined as an important input to horizontal molecular networks located at plasma membrane level.
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M3 - Article
AN - SCOPUS:35048825300
SN - 0302-9743
VL - 3146
SP - 24
EP - 54
JO - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
JF - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
ER -