On the dual contrast enhancement mechanism in frequency-selective inversion-recovery magnetic resonance angiography (IRON-MRA)

Evert Jan Vonken, Grigorios Korosoglou, Jing Yu, Michael Schär, Ralph Weissleder, Matthias Stuber

Research output: Contribution to journalArticle


The susceptibility of blood changes after administration of a paramagnetic contrast agent that shortens T1. Concomitantly, the resonance frequency of the blood vessels shifts in a geometry-dependent way. This frequency change may be exploited for incremental contrast generation by applying a frequency-selective saturation prepulse prior to the imaging sequence. The dual origin of vascular enhancement depending first on off-resonance and second on T1 lowering was investigated in vitro, together with the geometry dependence of the signal at 3T. First results obtained in an in vivo rabbit model are presented.

Original languageEnglish (US)
Pages (from-to)314-324
Number of pages11
JournalMagnetic resonance in medicine
Issue number2
StatePublished - Aug 1 2009



  • Background suppression
  • Blood-pool contrast agent
  • Magnetic resonance angiography
  • Off-resonance imaging
  • Susceptibility contrast

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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