'On' response defect in paraneoplastic night blindness with cutaneous malignant melanoma

K. R. Alexander, G. A. Fishman, N. S. Peachey, A. L. Marchese, M. O M Tso

Research output: Contribution to journalArticle

Abstract

Response properties of rod and cone systems were assessed in a patient with an acquired form of night blindness associated with a metastatic cutaneous malignant melanoma. The night blindness, a sensation of shimmering lights, and selective reductions in the amplitudes of both rod and cone electroretinographic (ERG) b-waves were present before and after chemotherapy, confirming that this disorder was a paraneoplastic consequence of the melanoma rather than a response to chemotherapy. During ERG testing with flashes of extended duration, the cone b-wave abnormality was found to be a predominant loss of the cone ERG 'on' response with relative preservation of the 'off' response, similar to that observed in patients with congenital stationary night blindness. An impairment in signal transmission specific for retinal 'on' pathways may be a primary defect in both of these forms of night blindness.

Original languageEnglish (US)
Pages (from-to)477-483
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume33
Issue number3
StatePublished - 1992
Externally publishedYes

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Night Blindness
Vertebrate Photoreceptor Cells
Drug Therapy
Melanoma
Light
Cutaneous Malignant Melanoma

Keywords

  • cones
  • cutaneous melanoma
  • electroretinogram
  • night blindness
  • paraneoplastic

ASJC Scopus subject areas

  • Ophthalmology

Cite this

'On' response defect in paraneoplastic night blindness with cutaneous malignant melanoma. / Alexander, K. R.; Fishman, G. A.; Peachey, N. S.; Marchese, A. L.; Tso, M. O M.

In: Investigative Ophthalmology and Visual Science, Vol. 33, No. 3, 1992, p. 477-483.

Research output: Contribution to journalArticle

Alexander, K. R. ; Fishman, G. A. ; Peachey, N. S. ; Marchese, A. L. ; Tso, M. O M. / 'On' response defect in paraneoplastic night blindness with cutaneous malignant melanoma. In: Investigative Ophthalmology and Visual Science. 1992 ; Vol. 33, No. 3. pp. 477-483.
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