On methodology and appropriate inference regarding possible genetic factors in typical, late-onset AD

Research output: Contribution to journalArticle

Abstract

Diagnosis of AD in both probands and relatives, and its typically late onset, pose difficulties for the interpretation of its apparent familial aggregation-a possible indicator of genetic causes. Recent methodologic improvements have ameliorated these difficulties somewhat, and new studies incorporating these improvements suggest much greater familial risk in AD than has been previously reported. Actual risk to aged relatives remains a topic of controversy, and the true role of genetic factors in the etiology of AD will probably require the application of the classical genetic methods of twin and linkage studies.

Original languageEnglish (US)
Pages (from-to)476-477
Number of pages2
JournalNeurobiology of Aging
Volume7
Issue number6
DOIs
StatePublished - 1986
Externally publishedYes

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Twin Studies

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

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abstract = "Diagnosis of AD in both probands and relatives, and its typically late onset, pose difficulties for the interpretation of its apparent familial aggregation-a possible indicator of genetic causes. Recent methodologic improvements have ameliorated these difficulties somewhat, and new studies incorporating these improvements suggest much greater familial risk in AD than has been previously reported. Actual risk to aged relatives remains a topic of controversy, and the true role of genetic factors in the etiology of AD will probably require the application of the classical genetic methods of twin and linkage studies.",
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year = "1986",
doi = "10.1016/0197-4580(86)90077-1",
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AB - Diagnosis of AD in both probands and relatives, and its typically late onset, pose difficulties for the interpretation of its apparent familial aggregation-a possible indicator of genetic causes. Recent methodologic improvements have ameliorated these difficulties somewhat, and new studies incorporating these improvements suggest much greater familial risk in AD than has been previously reported. Actual risk to aged relatives remains a topic of controversy, and the true role of genetic factors in the etiology of AD will probably require the application of the classical genetic methods of twin and linkage studies.

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