On a supplemented case-control design

Ruth M. Pfeiffer, Nilanjan Chatterjee

Research output: Contribution to journalArticle

Abstract

The supplemented case-control design consists of a case-control sample and of an additional sample of disease-free subjects who arise from a given stratum of one of the measured exposures in the case-control study. The supplemental data might, for example, arise from a population survey conducted independently of the case-control study. This design improves precision of estimates of main effects and especially of joint exposures, particularly when joint exposures are uncommon and the prevalence of one of the exposures is low. We first present a pseudo-likelihood estimator (PLE) that is easy to compute. We further adapt two-phase design methods to find maximum likelihood estimates (MLEs) for the log odds ratios for this design and derive asymptotic variance estimators that appropriately account for the differences in sampling schemes of this design from that of the traditional two-phase design. As an illustration of our design we present a study that was conducted to assess the influence to joint exposure of hepatitis-B virus (HBV) and hepatitis-C virus (HCV) infection on the risk of hepatocellular carcinoma in data from Qidong County, Jiangsu Province, China.

Original languageEnglish (US)
JournalBiometrics
Volume61
Issue number2
DOIs
StatePublished - Jun 2005
Externally publishedYes

Fingerprint

Case-control
Control Design
Joints
Case-Control Studies
Case-control Study
Likelihood Functions
Virus
Virus Diseases
Hepatitis B virus
Hepacivirus
case-control studies
Hepatocellular Carcinoma
Viruses
China
Pseudo-likelihood
Odds Ratio
Variance Estimator
Main Effect
Asymptotic Variance
Maximum Likelihood Estimate

Keywords

  • Logistic regression
  • Pseudo-likelihood
  • Stratified sampling
  • Two-phase design

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Mathematics
  • Statistics and Probability
  • Public Health, Environmental and Occupational Health

Cite this

On a supplemented case-control design. / Pfeiffer, Ruth M.; Chatterjee, Nilanjan.

In: Biometrics, Vol. 61, No. 2, 06.2005.

Research output: Contribution to journalArticle

Pfeiffer, Ruth M. ; Chatterjee, Nilanjan. / On a supplemented case-control design. In: Biometrics. 2005 ; Vol. 61, No. 2.
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