'Omic' approaches for unraveling signaling networks

Heng Zhu, Michael Snyder

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Signaling pathways are crucial for cell differentiation and response to cellular environments. Recently, a large number of approaches for the global analysis of genes and proteins have been described. These have provided important new insights into the components of different pathways and the molecular and cellular responses of these pathways. This review covers genomic and proteomic (collectively referred to as 'omic') approaches for the global analysis of cell signaling, including gene expression profiling and analysis, protein-protein interaction methods, protein microarrays, mass spectroscopy and gene-disruption and engineering approaches.

Original languageEnglish (US)
Pages (from-to)173-179
Number of pages7
JournalCurrent Opinion in Cell Biology
Issue number2
StatePublished - Apr 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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