Tratamiento del Helicobacter pylori con omeprazol, amoxicilina y claritromicina en esquemas de 7 y 10 días.

Translated title of the contribution: Omeprazole, amoxicillin and clarithromycin in the treatment of helicobacterpylori, in 7 and 10-day regimens

Wilson Rodríguez, Arturo Pareja Cruz, Luis Yushimito, Alberto Ramírez Ramos, Robert H. Gilman, José Watanabe Yamamoto, Carlos Rodríguez Ulloa, Daniel Mendoza Requena, José Guerra Valencia, Julio Leey Casella, Erick Chinga Alayo, Billie Velapatiño, Teresa Valencia

Research output: Contribution to journalArticle

Abstract

AIM: The most accepted treatment for infection by Helicobacter pylori is the proton pump inhibitor based therapy with two antibiotics. However, there is no consensus regarding the duration. The purpose here was to compare eradication percentages in the omeprazole+amoxicillin+clarithromycin regimen administered during 7 days versus 10 days and confront the results with a previous 14-day* experience in Peru. METHOD: Patients from the Central Military Hospital and Peruvian-Japanese Hospital evidencing chronic upper gastrointestinal tract symptoms were recruited. We excluded patients with peptic ulcer. Biopsies were taken for diagnosis, for urease and PCR tests, culture and coloring with silver. Omeprazole+clarithromycin+amoxicillin was used during 7 days versus 10 days. Control endoscopy was performed one month after treatment had been completed and molecular biology techniques were used to differentiate recurrences from new infections. Susceptibility to clarithromycin was assessed. RESULTS: 36 patients were included in each group. Eradication was the same in both groups: 86.1% (31/36). In several patients in whom the bacteria persisted, the same initial nucleus was found. In a previous study* using this same regimen during 14 days, a 93% eradication was obtained. 91.18% of our samples were susceptible to clarithromycin. CONCLUSIONS: In Peru, the omeprazole+clarithromycin+amoxicillin combination gives results higher than 80% in the eradication of infection by Helicobacter pylori. The 7 and 10 days regimens eradicated the bacteria in 86% of our patients.

Translated title of the contributionOmeprazole, amoxicillin and clarithromycin in the treatment of helicobacterpylori, in 7 and 10-day regimens
Original languageSpanish
Pages (from-to)177-183
Number of pages7
JournalRevista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
Volume23
Issue number3
StatePublished - Jan 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Rodríguez, W., Pareja Cruz, A., Yushimito, L., Ramírez Ramos, A., Gilman, R. H., Watanabe Yamamoto, J., Rodríguez Ulloa, C., Mendoza Requena, D., Guerra Valencia, J., Leey Casella, J., Chinga Alayo, E., Velapatiño, B., & Valencia, T. (2003). Tratamiento del Helicobacter pylori con omeprazol, amoxicilina y claritromicina en esquemas de 7 y 10 días. Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú, 23(3), 177-183.