Omega-3 fatty acids in adipose tissue and risk of myocardial infarction

The EURAMIC study

Eliseo Guallar, Antti Aro, F. Javier Jiménez, José M. Martín-Moreno, Irma Salminen, Pieter Van't Veer, Alwine F M Kardinaal, Jorge Gömez-Aracena, Biaise C. Martin, Lenore Kohlmeier, Jeremy D. Kark, Vladimir P. Mazaev, Jetmund Ringstad, José Guillén, Rudolph A. Riemersma, Jussi K. Huttunen, Michael Thamm, Frans J. Kok

Research output: Contribution to journalArticle

Abstract

Omega-3 fatty acids have potential antiatherogenic, antithrombotic, and antiarrhythmic properties, but their role in coronary heart disease remains controversial. To evaluate the association of omega-3 fatty acids in adipose tissue with the risk of myocardial infarction in men, a case-control study was conducted in eight European countries and Israel. Cases (n=639) included patients with a first myocardial infarction admitted to coronary care units within 24 hours from the onset of symptoms. Controls (n=700) were selected to represent the populations originating the cases. Adipose tissue levels of fatty acids were determined by capillary gas chromatography. The mean (±SD) proportion of α-linolenic acid was 0.77% (±0.19) of fatty acids in cases and 0.80% (±0.19) of fatty acids in controls (P=0.01). The relative risk for the highest quintile of α-linolenic acid compared with the lowest was 0.42 (95% confidence interval [CI] 0.22 to 0.81, P-trend=0.02). After adjusting for classical risk factors, the relative risk for the highest quintile was 0.68 (95% CI 0.31 to 1.49, P-trend=0.38). The mean proportion of docosahexaenoic acid was 0.24% (±0.13) of fatty acids in cases and 0.25% (±0.13) of fatty acids in controls (P=0.14), with no evidence of association with risk of myocardial infarction. In this large case-control study we could not detect a protective effect of docosahexaenoic acid on the risk of myocardial infarction. The protective effect of α-linolenic acid was attenuated after adjusting for classical risk factors (mainly smoking), but it deserves further research.

Original languageEnglish (US)
Pages (from-to)1111-1118
Number of pages8
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume19
Issue number4
StatePublished - Apr 1999
Externally publishedYes

Fingerprint

Omega-3 Fatty Acids
Adipose Tissue
Fatty Acids
Myocardial Infarction
alpha-Linolenic Acid
Docosahexaenoic Acids
Case-Control Studies
Confidence Intervals
Coronary Care Units
Israel
Gas Chromatography
Coronary Disease
Smoking
Research
Population

Keywords

  • α-linolenic acid
  • Adipose tissue
  • Case- control studies
  • Docosahexaenoic acid
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Guallar, E., Aro, A., Jiménez, F. J., Martín-Moreno, J. M., Salminen, I., Van't Veer, P., ... Kok, F. J. (1999). Omega-3 fatty acids in adipose tissue and risk of myocardial infarction: The EURAMIC study. Arteriosclerosis, Thrombosis, and Vascular Biology, 19(4), 1111-1118.

Omega-3 fatty acids in adipose tissue and risk of myocardial infarction : The EURAMIC study. / Guallar, Eliseo; Aro, Antti; Jiménez, F. Javier; Martín-Moreno, José M.; Salminen, Irma; Van't Veer, Pieter; Kardinaal, Alwine F M; Gömez-Aracena, Jorge; Martin, Biaise C.; Kohlmeier, Lenore; Kark, Jeremy D.; Mazaev, Vladimir P.; Ringstad, Jetmund; Guillén, José; Riemersma, Rudolph A.; Huttunen, Jussi K.; Thamm, Michael; Kok, Frans J.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 19, No. 4, 04.1999, p. 1111-1118.

Research output: Contribution to journalArticle

Guallar, E, Aro, A, Jiménez, FJ, Martín-Moreno, JM, Salminen, I, Van't Veer, P, Kardinaal, AFM, Gömez-Aracena, J, Martin, BC, Kohlmeier, L, Kark, JD, Mazaev, VP, Ringstad, J, Guillén, J, Riemersma, RA, Huttunen, JK, Thamm, M & Kok, FJ 1999, 'Omega-3 fatty acids in adipose tissue and risk of myocardial infarction: The EURAMIC study', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 19, no. 4, pp. 1111-1118.
Guallar E, Aro A, Jiménez FJ, Martín-Moreno JM, Salminen I, Van't Veer P et al. Omega-3 fatty acids in adipose tissue and risk of myocardial infarction: The EURAMIC study. Arteriosclerosis, Thrombosis, and Vascular Biology. 1999 Apr;19(4):1111-1118.
Guallar, Eliseo ; Aro, Antti ; Jiménez, F. Javier ; Martín-Moreno, José M. ; Salminen, Irma ; Van't Veer, Pieter ; Kardinaal, Alwine F M ; Gömez-Aracena, Jorge ; Martin, Biaise C. ; Kohlmeier, Lenore ; Kark, Jeremy D. ; Mazaev, Vladimir P. ; Ringstad, Jetmund ; Guillén, José ; Riemersma, Rudolph A. ; Huttunen, Jussi K. ; Thamm, Michael ; Kok, Frans J. / Omega-3 fatty acids in adipose tissue and risk of myocardial infarction : The EURAMIC study. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 1999 ; Vol. 19, No. 4. pp. 1111-1118.
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