TY - JOUR
T1 - Omega-3 and omega-6 intake modifies asthma severity and response to indoor air pollution in children
AU - Brigham, Emily P.
AU - Woo, Han
AU - McCormack, Meredith
AU - Rice, Jessica
AU - Koehler, Kirsten
AU - Vulcain, Tristan
AU - Wu, Tianshi
AU - Koch, Abigail
AU - Sharma, Sangita
AU - Kolahdooz, Fariba
AU - Bose, Sonali
AU - Hanson, Corrine
AU - Romero, Karina
AU - Diette, Gregory
AU - Hansel, Nadia N.
N1 - Publisher Copyright:
Copyright © 2019 by the American Thoracic Society.
PY - 2019/6/15
Y1 - 2019/6/15
N2 - Rationale: Higher indoor particulate matter (PM) concentrations are linked with increased asthma morbidity. Dietary intake of fatty acids, also linked with asthma outcomes, may influence this relationship. Objectives: To determine the relationship between omega-3 and omega-6 fatty acid intake and pediatric asthma morbidity, and the association between fatty acid intake and strength of indoor, PM-related asthma symptoms, albuterol use, and systemic inflammation. Methods: Analyses included 135 children with asthma enrolled in the AsthmaDIET Study. At baseline, 3 months, and 6 months, data included: week-long average home indoor concentration of PM <2.5 mm in aerodynamic diameter and PM <10 mm in aerodynamic diameter, dietary intake of omega-3 and omega-6 fatty acids, daily symptoms, and peripheral blood leukocytes. Asthma severity and lung function were assessed at baseline. Multivariable regression models, adjusted for known confounders, were used to determine associations between each fatty acid and outcomes of interest, with interaction terms (fatty acids 3 PM) in longitudinal analyses. Measurements and Main Results: Higher omega-6 intake associated with increased odds of increased asthma severity (P = 0.02), and lower FEV1/FVC ratio (P = 0.01). Higher omega-3 intake associated with reduced effect of indoor PM <2.5 mm in aerodynamic diameter on symptoms (P, 0.01), whereas higher omega-6 intake associated with amplified effect of indoor PM <2.5 mm in aerodynamic diameter on symptoms and circulating neutrophil percentage (P, 0.01). Conclusions: Omega-3 and omega-6 intake are associated with pediatric asthma morbidity and may modify the asthmatic response to indoor PM.
AB - Rationale: Higher indoor particulate matter (PM) concentrations are linked with increased asthma morbidity. Dietary intake of fatty acids, also linked with asthma outcomes, may influence this relationship. Objectives: To determine the relationship between omega-3 and omega-6 fatty acid intake and pediatric asthma morbidity, and the association between fatty acid intake and strength of indoor, PM-related asthma symptoms, albuterol use, and systemic inflammation. Methods: Analyses included 135 children with asthma enrolled in the AsthmaDIET Study. At baseline, 3 months, and 6 months, data included: week-long average home indoor concentration of PM <2.5 mm in aerodynamic diameter and PM <10 mm in aerodynamic diameter, dietary intake of omega-3 and omega-6 fatty acids, daily symptoms, and peripheral blood leukocytes. Asthma severity and lung function were assessed at baseline. Multivariable regression models, adjusted for known confounders, were used to determine associations between each fatty acid and outcomes of interest, with interaction terms (fatty acids 3 PM) in longitudinal analyses. Measurements and Main Results: Higher omega-6 intake associated with increased odds of increased asthma severity (P = 0.02), and lower FEV1/FVC ratio (P = 0.01). Higher omega-3 intake associated with reduced effect of indoor PM <2.5 mm in aerodynamic diameter on symptoms (P, 0.01), whereas higher omega-6 intake associated with amplified effect of indoor PM <2.5 mm in aerodynamic diameter on symptoms and circulating neutrophil percentage (P, 0.01). Conclusions: Omega-3 and omega-6 intake are associated with pediatric asthma morbidity and may modify the asthmatic response to indoor PM.
KW - Diet
KW - Inflammation
KW - Particulate matter
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U2 - 10.1164/rccm.201808-1474OC
DO - 10.1164/rccm.201808-1474OC
M3 - Article
C2 - 30922077
AN - SCOPUS:85067309861
SN - 1073-449X
VL - 199
SP - 1478
EP - 1486
JO - American journal of respiratory and critical care medicine
JF - American journal of respiratory and critical care medicine
IS - 12
ER -