Oligometastatic prostate cancer: definitions, clinical outcomes, and treatment considerations

Jeffrey J. Tosoian, Michael Gorin, Ashley E. Ross, Kenneth Pienta, Phuoc T Tran, Edward M. Schaeffer

Research output: Contribution to journalArticle

Abstract

The oligometastatic state has been proposed as an intermediate stage of cancer spread between localized disease and widespread metastases. With improvements in diagnostic modalities such as functional imaging, oligometastatic prostate cancer is being diagnosed with greater frequency than ever before. Furthermore, the paradigm for treatment of advanced prostate cancers is shifting toward a more aggressive approach. Many questions surround the understanding of the process and consequences of oligometastasis, meaning that the contemporary literature offers a wide variety of definitions of oligometastatic prostate cancer. Until genomic data exist to provide a biological component to the definition of oligometastatic disease, a clinical diagnosis made on the basis of up to five extrapelvic lesions is reasonable for use. Retrospective studies suggest that interventions such as radical prostatectomy and local or metastasis-directed radiotherapy can be performed in the metastatic setting with minimal risk of toxic effects. These therapies seem to decrease the need for subsequent palliative interventions, but insufficient data are available to draw reliable conclusions regarding their effect on survival. Thus, a protocol for clinicians to manage the patient presenting with oligometastatic prostate cancer would be a useful clinical tool.

Original languageEnglish (US)
JournalNature Reviews Urology
DOIs
StateAccepted/In press - Oct 11 2016

Fingerprint

Prostatic Neoplasms
Neoplasm Metastasis
Literature
Poisons
Prostatectomy
Radiotherapy
Retrospective Studies
Survival
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Oligometastatic prostate cancer : definitions, clinical outcomes, and treatment considerations. / Tosoian, Jeffrey J.; Gorin, Michael; Ross, Ashley E.; Pienta, Kenneth; Tran, Phuoc T; Schaeffer, Edward M.

In: Nature Reviews Urology, 11.10.2016.

Research output: Contribution to journalArticle

@article{cff6ff25dcbd41929420eda353fd1ad8,
title = "Oligometastatic prostate cancer: definitions, clinical outcomes, and treatment considerations",
abstract = "The oligometastatic state has been proposed as an intermediate stage of cancer spread between localized disease and widespread metastases. With improvements in diagnostic modalities such as functional imaging, oligometastatic prostate cancer is being diagnosed with greater frequency than ever before. Furthermore, the paradigm for treatment of advanced prostate cancers is shifting toward a more aggressive approach. Many questions surround the understanding of the process and consequences of oligometastasis, meaning that the contemporary literature offers a wide variety of definitions of oligometastatic prostate cancer. Until genomic data exist to provide a biological component to the definition of oligometastatic disease, a clinical diagnosis made on the basis of up to five extrapelvic lesions is reasonable for use. Retrospective studies suggest that interventions such as radical prostatectomy and local or metastasis-directed radiotherapy can be performed in the metastatic setting with minimal risk of toxic effects. These therapies seem to decrease the need for subsequent palliative interventions, but insufficient data are available to draw reliable conclusions regarding their effect on survival. Thus, a protocol for clinicians to manage the patient presenting with oligometastatic prostate cancer would be a useful clinical tool.",
author = "Tosoian, {Jeffrey J.} and Michael Gorin and Ross, {Ashley E.} and Kenneth Pienta and Tran, {Phuoc T} and Schaeffer, {Edward M.}",
year = "2016",
month = "10",
day = "11",
doi = "10.1038/nrurol.2016.175",
language = "English (US)",
journal = "Nature Reviews Urology",
issn = "1759-4812",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Oligometastatic prostate cancer

T2 - definitions, clinical outcomes, and treatment considerations

AU - Tosoian, Jeffrey J.

AU - Gorin, Michael

AU - Ross, Ashley E.

AU - Pienta, Kenneth

AU - Tran, Phuoc T

AU - Schaeffer, Edward M.

PY - 2016/10/11

Y1 - 2016/10/11

N2 - The oligometastatic state has been proposed as an intermediate stage of cancer spread between localized disease and widespread metastases. With improvements in diagnostic modalities such as functional imaging, oligometastatic prostate cancer is being diagnosed with greater frequency than ever before. Furthermore, the paradigm for treatment of advanced prostate cancers is shifting toward a more aggressive approach. Many questions surround the understanding of the process and consequences of oligometastasis, meaning that the contemporary literature offers a wide variety of definitions of oligometastatic prostate cancer. Until genomic data exist to provide a biological component to the definition of oligometastatic disease, a clinical diagnosis made on the basis of up to five extrapelvic lesions is reasonable for use. Retrospective studies suggest that interventions such as radical prostatectomy and local or metastasis-directed radiotherapy can be performed in the metastatic setting with minimal risk of toxic effects. These therapies seem to decrease the need for subsequent palliative interventions, but insufficient data are available to draw reliable conclusions regarding their effect on survival. Thus, a protocol for clinicians to manage the patient presenting with oligometastatic prostate cancer would be a useful clinical tool.

AB - The oligometastatic state has been proposed as an intermediate stage of cancer spread between localized disease and widespread metastases. With improvements in diagnostic modalities such as functional imaging, oligometastatic prostate cancer is being diagnosed with greater frequency than ever before. Furthermore, the paradigm for treatment of advanced prostate cancers is shifting toward a more aggressive approach. Many questions surround the understanding of the process and consequences of oligometastasis, meaning that the contemporary literature offers a wide variety of definitions of oligometastatic prostate cancer. Until genomic data exist to provide a biological component to the definition of oligometastatic disease, a clinical diagnosis made on the basis of up to five extrapelvic lesions is reasonable for use. Retrospective studies suggest that interventions such as radical prostatectomy and local or metastasis-directed radiotherapy can be performed in the metastatic setting with minimal risk of toxic effects. These therapies seem to decrease the need for subsequent palliative interventions, but insufficient data are available to draw reliable conclusions regarding their effect on survival. Thus, a protocol for clinicians to manage the patient presenting with oligometastatic prostate cancer would be a useful clinical tool.

UR - http://www.scopus.com/inward/record.url?scp=84991030687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991030687&partnerID=8YFLogxK

U2 - 10.1038/nrurol.2016.175

DO - 10.1038/nrurol.2016.175

M3 - Article

C2 - 27725639

AN - SCOPUS:84991030687

JO - Nature Reviews Urology

JF - Nature Reviews Urology

SN - 1759-4812

ER -