(Oligo)metastasis as a spectrum of disease

Stanley I. Gutiontov, Sean P. Pitroda, Phuoc T. Tran, Ralph R. Weichselbaum

Research output: Contribution to journalReview articlepeer-review


Cancer metastasis is the leading cause of cancer-related mortality, and most patients with metastases from solid tumors have historically been considered incurable. Here, we discuss the evolution of our understanding of the oligometastatic state with an emphasis on the view that cancer metastasis represents a spectrum of disease. We highlight several recently published prospective clinical trials demonstrating improvements in cancer-specific outcomes with the utilization of metastasis-directed local therapies. We discuss biological aspects of oligometastases, including genetic, epigenetic, and immune determinants of the metastatic spectrum. Finally, we propose future considerations regarding clinical trial design for patients with oligometastatic disease.

Original languageEnglish (US)
Pages (from-to)2577-2583
Number of pages7
JournalCancer Research
Issue number10
StatePublished - May 2021

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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