TY - JOUR
T1 - Olfactory, taste, and photo sensory receptors in non-sensory organs
T2 - It just makes sense
AU - Dalesio, Nicholas M.
AU - Barreto Ortiz, Sebastian F.
AU - Pluznick, Jennifer L.
AU - Berkowitz, Dan E.
N1 - Publisher Copyright:
© 2018 Dalesio, Barreto Ortiz, Pluznick and Berkowitz.
PY - 2018
Y1 - 2018
N2 - Sensory receptors that detect and respond to light, taste, and smell primarily belong to the G-protein-coupled receptor (GPCR) superfamily. In addition to their established roles in the nose, tongue, and eyes, these sensory GPCRs have been found in many ‘non-sensory’ organs where they respond to different physicochemical stimuli, initiating signaling cascades in these extrasensory systems. For example, taste receptors in the airway, and photoreceptors in vascular smooth muscle cells, both cause smooth muscle relaxation when activated. In addition, olfactory receptors are present within the vascular system, where they play roles in angiogenesis as well as in modulating vascular tone. By better understanding the physiological and pathophysiological roles of sensory receptors in non-sensory organs, novel therapeutic agents can be developed targeting these receptors, ultimately leading to treatments for pathological conditions and potential cures for various disease states.
AB - Sensory receptors that detect and respond to light, taste, and smell primarily belong to the G-protein-coupled receptor (GPCR) superfamily. In addition to their established roles in the nose, tongue, and eyes, these sensory GPCRs have been found in many ‘non-sensory’ organs where they respond to different physicochemical stimuli, initiating signaling cascades in these extrasensory systems. For example, taste receptors in the airway, and photoreceptors in vascular smooth muscle cells, both cause smooth muscle relaxation when activated. In addition, olfactory receptors are present within the vascular system, where they play roles in angiogenesis as well as in modulating vascular tone. By better understanding the physiological and pathophysiological roles of sensory receptors in non-sensory organs, novel therapeutic agents can be developed targeting these receptors, ultimately leading to treatments for pathological conditions and potential cures for various disease states.
KW - Bitter taste receptor
KW - G-protein couple receptor
KW - Olfactory receptor (OR)
KW - Opsins
KW - Sensory receptor
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U2 - 10.3389/fphys.2018.01673
DO - 10.3389/fphys.2018.01673
M3 - Review article
AN - SCOPUS:85064325574
SN - 1664-042X
VL - 9
SP - 1
EP - 19
JO - Frontiers in Physiology
JF - Frontiers in Physiology
M1 - 1673
ER -