Olfactory dysfunction in multiple sclerosis: Relation to longitudinal changes in plaque numbers in central olfactory structures

Richard L. Doty; Cheng Li; Lois J. Mannon; David M. Yousem

doi:10.1212/wnl.53.4.880

Olfactory dysfunction in multiple sclerosis: Relation to longitudinal changes in plaque numbers in central olfactory structures

Richard L. Doty, Cheng Li, Lois J. Mannon, David M. Yousem

School of Medicine

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Scores on the University of Pennsylvania Smell Identification Test (UPSIT), as well as the numbers of MRI-determined plaques within the inferior frontal and temporal lobes, were obtained on three or four separate occasions in each of five MS patients over an 18- to 20-month period. A close association was observed, longitudinally, between the remission and exacerbation of plaque numbers and UPSIT scores, with more plaques reflecting lower UPSIT scores. These observations further support the hypothesis that olfactory loss in MS is associated with fluctuations in plaque numbers in central olfactory brain regions.

Original language	English (US)
Pages (from-to)	880-882
Number of pages	3
Journal	Neurology
Volume	53
Issue number	4
DOIs	https://doi.org/10.1212/wnl.53.4.880
State	Published - Sep 11 1999

Keywords

MS
Olfactory dysfunction
Plaque numbers

ASJC Scopus subject areas

Clinical Neurology

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10.1212/wnl.53.4.880

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abstract = "Scores on the University of Pennsylvania Smell Identification Test (UPSIT), as well as the numbers of MRI-determined plaques within the inferior frontal and temporal lobes, were obtained on three or four separate occasions in each of five MS patients over an 18- to 20-month period. A close association was observed, longitudinally, between the remission and exacerbation of plaque numbers and UPSIT scores, with more plaques reflecting lower UPSIT scores. These observations further support the hypothesis that olfactory loss in MS is associated with fluctuations in plaque numbers in central olfactory brain regions.",

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AU - Li, Cheng

AU - Mannon, Lois J.

AU - Yousem, David M.

PY - 1999/9/11

Y1 - 1999/9/11

N2 - Scores on the University of Pennsylvania Smell Identification Test (UPSIT), as well as the numbers of MRI-determined plaques within the inferior frontal and temporal lobes, were obtained on three or four separate occasions in each of five MS patients over an 18- to 20-month period. A close association was observed, longitudinally, between the remission and exacerbation of plaque numbers and UPSIT scores, with more plaques reflecting lower UPSIT scores. These observations further support the hypothesis that olfactory loss in MS is associated with fluctuations in plaque numbers in central olfactory brain regions.

AB - Scores on the University of Pennsylvania Smell Identification Test (UPSIT), as well as the numbers of MRI-determined plaques within the inferior frontal and temporal lobes, were obtained on three or four separate occasions in each of five MS patients over an 18- to 20-month period. A close association was observed, longitudinally, between the remission and exacerbation of plaque numbers and UPSIT scores, with more plaques reflecting lower UPSIT scores. These observations further support the hypothesis that olfactory loss in MS is associated with fluctuations in plaque numbers in central olfactory brain regions.

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KW - Olfactory dysfunction

KW - Plaque numbers

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Olfactory dysfunction in multiple sclerosis: Relation to longitudinal changes in plaque numbers in central olfactory structures

Abstract

Keywords

ASJC Scopus subject areas

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