Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: Utility and limitation of the surrogate tissues in research for brain disorders

Yasue Horiuchi, Shin ichi Kano, Koko Ishizuka, Nicola G. Cascella, Seiji Ishii, C Conover Talbot, Andrew E. Jaffe, Hideyuki Okano, Jonathan Pevsner, Carlo Colantuoni, Akira Sawa

Research output: Contribution to journalArticle

Abstract

Human olfactory cells obtained by rapid nasal biopsy have been suggested to be a good surrogate system to address brain disease-associated molecular changes. Nonetheless, whether use of this experimental strategy is justified remains unclear. Here we compared expression profiles of olfactory cells systematically with those from the brain tissues and other cells. Principal component analysis indicated that the expression profiles of olfactory cells are very different from those of blood cells, but are closer to those of stem cells, in particular mesenchymal stem cells, that can be differentiated into the cells of the central nervous system.

Original languageEnglish (US)
Pages (from-to)247-250
Number of pages4
JournalNeuroscience Research
Volume77
Issue number4
DOIs
StatePublished - Dec 1 2013

Keywords

  • Bipolar disorder
  • Gene expression profile
  • Lymphoblasts
  • Olfactory cells
  • Schizophrenia
  • Stem cells

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: Utility and limitation of the surrogate tissues in research for brain disorders'. Together they form a unique fingerprint.

  • Cite this