Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: Utility and limitation of the surrogate tissues in research for brain disorders

Yasue Horiuchi; Shin ichi Kano; Koko Ishizuka; Nicola G. Cascella; Seiji Ishii; C. Conover Talbot; Andrew E. Jaffe; Hideyuki Okano; Jonathan Pevsner; Carlo Colantuoni; Akira Sawa

doi:10.1016/j.neures.2013.09.010

Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: Utility and limitation of the surrogate tissues in research for brain disorders

Yasue Horiuchi, Shin ichi Kano, Koko Ishizuka, Nicola G. Cascella, Seiji Ishii, C. Conover Talbot, Andrew E. Jaffe, Hideyuki Okano, Jonathan Pevsner, Carlo Colantuoni, Akira Sawa

School of Medicine

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Human olfactory cells obtained by rapid nasal biopsy have been suggested to be a good surrogate system to address brain disease-associated molecular changes. Nonetheless, whether use of this experimental strategy is justified remains unclear. Here we compared expression profiles of olfactory cells systematically with those from the brain tissues and other cells. Principal component analysis indicated that the expression profiles of olfactory cells are very different from those of blood cells, but are closer to those of stem cells, in particular mesenchymal stem cells, that can be differentiated into the cells of the central nervous system.

Original language	English (US)
Pages (from-to)	247-250
Number of pages	4
Journal	Neuroscience Research
Volume	77
Issue number	4
DOIs	https://doi.org/10.1016/j.neures.2013.09.010
State	Published - Dec 2013

Keywords

Bipolar disorder
Gene expression profile
Lymphoblasts
Olfactory cells
Schizophrenia
Stem cells

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/j.neures.2013.09.010

Cite this

Horiuchi, Y., Kano, S. I., Ishizuka, K., Cascella, N. G., Ishii, S., Talbot, C. C., Jaffe, A. E., Okano, H., Pevsner, J., Colantuoni, C., & Sawa, A. (2013). Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: Utility and limitation of the surrogate tissues in research for brain disorders. Neuroscience Research, 77(4), 247-250. https://doi.org/10.1016/j.neures.2013.09.010

Horiuchi, Y, Kano, SI, Ishizuka, K , Cascella, NG, Ishii, S, Talbot, CC, Jaffe, AE, Okano, H, Pevsner, J, Colantuoni, C & Sawa, A 2013, 'Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: Utility and limitation of the surrogate tissues in research for brain disorders', Neuroscience Research, vol. 77, no. 4, pp. 247-250. https://doi.org/10.1016/j.neures.2013.09.010

@article{a44d0ebe1be341e28394c00628b2ac19,

title = "Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: Utility and limitation of the surrogate tissues in research for brain disorders",

abstract = "Human olfactory cells obtained by rapid nasal biopsy have been suggested to be a good surrogate system to address brain disease-associated molecular changes. Nonetheless, whether use of this experimental strategy is justified remains unclear. Here we compared expression profiles of olfactory cells systematically with those from the brain tissues and other cells. Principal component analysis indicated that the expression profiles of olfactory cells are very different from those of blood cells, but are closer to those of stem cells, in particular mesenchymal stem cells, that can be differentiated into the cells of the central nervous system.",

keywords = "Bipolar disorder, Gene expression profile, Lymphoblasts, Olfactory cells, Schizophrenia, Stem cells",

author = "Yasue Horiuchi and Kano, {Shin ichi} and Koko Ishizuka and Cascella, {Nicola G.} and Seiji Ishii and Talbot, {C. Conover} and Jaffe, {Andrew E.} and Hideyuki Okano and Jonathan Pevsner and Carlo Colantuoni and Akira Sawa",

note = "Funding Information: We thank Dr. Pamela Talalay for critical reading of this manuscript. We appreciate Yukiko Y. Lema for organizing the figures and manuscript. This work was supported by USPHS grants MH-084018 (A.S.), MH-094268 Silvo O. Conte Center (A.S.), MH-069853 (A.S.), MH-085226 (A.S.), MH-088753 (A.S.), MH-092443 (A.S.), MH-096208 (K.I.) and K99MH-093458 (S.-I.K.), grants from Stanley (A.S.), RUSK (A.S.), S-R Foundations (A.S.), NARSAD (A.S., S.-I.K., and K.I.), the Japanese Ministry of Education, Culture, Sports, Science and Technology (H.O.) and Maryland Stem Cell Research Fund (A.S., Y.H., and K.I.). S.-I.K. is also supported by the Hammerschlag family (S.-I.K),",

year = "2013",

month = dec,

doi = "10.1016/j.neures.2013.09.010",

language = "English (US)",

volume = "77",

pages = "247--250",

journal = "Neuroscience Research",

issn = "0168-0102",

publisher = "Elsevier Ireland Ltd",

number = "4",

}

TY - JOUR

T1 - Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles

T2 - Utility and limitation of the surrogate tissues in research for brain disorders

AU - Horiuchi, Yasue

AU - Kano, Shin ichi

AU - Ishizuka, Koko

AU - Cascella, Nicola G.

AU - Ishii, Seiji

AU - Talbot, C. Conover

AU - Jaffe, Andrew E.

AU - Okano, Hideyuki

AU - Pevsner, Jonathan

AU - Colantuoni, Carlo

AU - Sawa, Akira

N1 - Funding Information: We thank Dr. Pamela Talalay for critical reading of this manuscript. We appreciate Yukiko Y. Lema for organizing the figures and manuscript. This work was supported by USPHS grants MH-084018 (A.S.), MH-094268 Silvo O. Conte Center (A.S.), MH-069853 (A.S.), MH-085226 (A.S.), MH-088753 (A.S.), MH-092443 (A.S.), MH-096208 (K.I.) and K99MH-093458 (S.-I.K.), grants from Stanley (A.S.), RUSK (A.S.), S-R Foundations (A.S.), NARSAD (A.S., S.-I.K., and K.I.), the Japanese Ministry of Education, Culture, Sports, Science and Technology (H.O.) and Maryland Stem Cell Research Fund (A.S., Y.H., and K.I.). S.-I.K. is also supported by the Hammerschlag family (S.-I.K),

PY - 2013/12

Y1 - 2013/12

N2 - Human olfactory cells obtained by rapid nasal biopsy have been suggested to be a good surrogate system to address brain disease-associated molecular changes. Nonetheless, whether use of this experimental strategy is justified remains unclear. Here we compared expression profiles of olfactory cells systematically with those from the brain tissues and other cells. Principal component analysis indicated that the expression profiles of olfactory cells are very different from those of blood cells, but are closer to those of stem cells, in particular mesenchymal stem cells, that can be differentiated into the cells of the central nervous system.

AB - Human olfactory cells obtained by rapid nasal biopsy have been suggested to be a good surrogate system to address brain disease-associated molecular changes. Nonetheless, whether use of this experimental strategy is justified remains unclear. Here we compared expression profiles of olfactory cells systematically with those from the brain tissues and other cells. Principal component analysis indicated that the expression profiles of olfactory cells are very different from those of blood cells, but are closer to those of stem cells, in particular mesenchymal stem cells, that can be differentiated into the cells of the central nervous system.

KW - Bipolar disorder

KW - Gene expression profile

KW - Lymphoblasts

KW - Olfactory cells

KW - Schizophrenia

KW - Stem cells

UR - http://www.scopus.com/inward/record.url?scp=84888339088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888339088&partnerID=8YFLogxK

U2 - 10.1016/j.neures.2013.09.010

DO - 10.1016/j.neures.2013.09.010

M3 - Article

C2 - 24120685

AN - SCOPUS:84888339088

SN - 0168-0102

VL - 77

SP - 247

EP - 250

JO - Neuroscience Research

JF - Neuroscience Research

IS - 4

ER -

Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: Utility and limitation of the surrogate tissues in research for brain disorders

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this