Olfactory bulbectomy protects hippocampal pyramidal neurons against excitotoxic death

Devin S. Gary, Thomas V. Getchell, Marilyn L. Getchell, Mark P. Mattson

Research output: Contribution to journalArticle

Abstract

The olfactory system is functionally linked to the hippocampus, and odors can modify the activity of hippocampal neurons. Because hippocampal neurons are selectively vulnerable to death in several prominent neurodegenerative conditions, we tested the hypothesis that activity in olfactory pathways can modify the sensitivity of hippocampal neurons to excitotoxic damage. We report that rats subjected to olfactory bulbectomy exhibit a decrease in the vulnerability of hippocampal pyramidal neurons to excitotoxic injury. Four-month-old male Sprague-Dawley rats were subjected to bilateral olfactory bulbectomy or a sham operation. Three months later the rats were given a unilateral infusion of kainic acid in the dorsal hippocampus and were euthanized 24 h later. There was a threefold increase in the number of CA3 neurons that survived kainic acid administration in the bulbectomized rats compared to sham-operated rats. These findings provide the first evidence that olfactory input affects the vulnerability of neurons to excitotoxic death.

Original languageEnglish (US)
Pages (from-to)266-268
Number of pages3
JournalExperimental Neurology
Volume176
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Pyramidal Cells
Neurons
Kainic Acid
Hippocampus
Olfactory Pathways
Sprague Dawley Rats
Wounds and Injuries

Keywords

  • Apoptosis
  • Epilepsy
  • Glutamate
  • Kainic acid
  • Learning and memory
  • Olfaction

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

Cite this

Olfactory bulbectomy protects hippocampal pyramidal neurons against excitotoxic death. / Gary, Devin S.; Getchell, Thomas V.; Getchell, Marilyn L.; Mattson, Mark P.

In: Experimental Neurology, Vol. 176, No. 1, 2002, p. 266-268.

Research output: Contribution to journalArticle

Gary, Devin S. ; Getchell, Thomas V. ; Getchell, Marilyn L. ; Mattson, Mark P. / Olfactory bulbectomy protects hippocampal pyramidal neurons against excitotoxic death. In: Experimental Neurology. 2002 ; Vol. 176, No. 1. pp. 266-268.
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