Olfactory bulb proteins linked to olfactory memory in C57BL/6J mice

Lin Li, Veronika Mauric, Jun Fang Zheng, Sung Ung Kang, Sudarshan Patil, Harald Höger, Gert Lubec

Research output: Contribution to journalArticlepeer-review


Information on systematic analysis of olfactory memory-related proteins is poor. In this study, the odor discrimination task to investigate olfactory recognition memory of adult male C57BL/6J mice was used. Subsequently, olfactory bulbs (OBs) were taken, proteins extracted, and run on two-dimensional gel electrophoresis with in-gel-protein digestion, followed by mass spectrom-etry and quantification of differentially expressed proteins. Dual specificity mitogen-activated protein kinase kinase 1 (MEK1), dihydropyrimidinase-related protein 1 (DRP1), and fascin are related with Lemon odor memory. Micro-tubule-associated protein RP/EB family member 3 is related to Rose odor memory. Hypoxanthine-guanine phosphoribosyltransferase is related with both Lemon and Rose odors memory. MEK1 and DRP1 levels were increased, while microtubule-associated protein RP/EB family member 3, fascin and hypoxanthine-guanine phosphoribosyltransferase levels were decreased during olfactory memory. In summary, neurogenesis, signal transduction, cytoskeleton, and nucleotide metabolism are involved in olfactory memory formation and storage of C57BL/6J mice.

Original languageEnglish (US)
Pages (from-to)871-886
Number of pages16
JournalAmino Acids
Issue number3
StatePublished - Aug 2010
Externally publishedYes


  • C57BL/6J mice
  • Olfactory bulb
  • Olfactory discrimination task
  • Olfactory memory

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Olfactory bulb proteins linked to olfactory memory in C57BL/6J mice'. Together they form a unique fingerprint.

Cite this