Olfaction in the kidney: 'Smelling' gut microbial metabolites

Niranjana Natarajan, Jennifer Pluznick

Research output: Contribution to journalArticle

Abstract

New Findings: What is the topic of this review? This review covers recent findings highlighting roles for renal and vascular sensory receptors that modify blood pressure control in response to changes in gut microbial metabolites. What advances does it highlight? This review highlights the novel roles that G-protein-coupled receptor 41 and olfactory receptor 78 play in blood pressure regulation. The gut microbiota have recently been recognized as an important component of host physiology and pathophysiology. Our recent studies have shown that a subset of gut microbial metabolites, known as short-chain fatty acids, act as ligands for host G-protein-coupled receptors (G-protein-coupled receptor 41 and olfactory receptor 78). Short-chain fatty acid-mediated activation of G-protein-coupled receptor 41 and olfactory receptor 78 modulates blood pressure control, both by modulating renin secretion and by modulating vascular tone directly. Further studies are needed in order to gain a better understanding of the underlying mechanism by which microbiota and microbial metabolites modulate host physiology and their potential implications in health and disease.

Original languageEnglish (US)
JournalExperimental Physiology
DOIs
StateAccepted/In press - 2015

Fingerprint

Smell
Odorant Receptors
G-Protein-Coupled Receptors
Kidney
Volatile Fatty Acids
Blood Pressure
Blood Vessels
Microbiota
Sensory Receptor Cells
Renin
Ligands
Health

ASJC Scopus subject areas

  • Physiology

Cite this

Olfaction in the kidney : 'Smelling' gut microbial metabolites. / Natarajan, Niranjana; Pluznick, Jennifer.

In: Experimental Physiology, 2015.

Research output: Contribution to journalArticle

@article{8173e5c144034597860df19cc17d3056,
title = "Olfaction in the kidney: 'Smelling' gut microbial metabolites",
abstract = "New Findings: What is the topic of this review? This review covers recent findings highlighting roles for renal and vascular sensory receptors that modify blood pressure control in response to changes in gut microbial metabolites. What advances does it highlight? This review highlights the novel roles that G-protein-coupled receptor 41 and olfactory receptor 78 play in blood pressure regulation. The gut microbiota have recently been recognized as an important component of host physiology and pathophysiology. Our recent studies have shown that a subset of gut microbial metabolites, known as short-chain fatty acids, act as ligands for host G-protein-coupled receptors (G-protein-coupled receptor 41 and olfactory receptor 78). Short-chain fatty acid-mediated activation of G-protein-coupled receptor 41 and olfactory receptor 78 modulates blood pressure control, both by modulating renin secretion and by modulating vascular tone directly. Further studies are needed in order to gain a better understanding of the underlying mechanism by which microbiota and microbial metabolites modulate host physiology and their potential implications in health and disease.",
author = "Niranjana Natarajan and Jennifer Pluznick",
year = "2015",
doi = "10.1113/EP085285",
language = "English (US)",
journal = "Experimental Physiology",
issn = "0958-0670",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Olfaction in the kidney

T2 - 'Smelling' gut microbial metabolites

AU - Natarajan, Niranjana

AU - Pluznick, Jennifer

PY - 2015

Y1 - 2015

N2 - New Findings: What is the topic of this review? This review covers recent findings highlighting roles for renal and vascular sensory receptors that modify blood pressure control in response to changes in gut microbial metabolites. What advances does it highlight? This review highlights the novel roles that G-protein-coupled receptor 41 and olfactory receptor 78 play in blood pressure regulation. The gut microbiota have recently been recognized as an important component of host physiology and pathophysiology. Our recent studies have shown that a subset of gut microbial metabolites, known as short-chain fatty acids, act as ligands for host G-protein-coupled receptors (G-protein-coupled receptor 41 and olfactory receptor 78). Short-chain fatty acid-mediated activation of G-protein-coupled receptor 41 and olfactory receptor 78 modulates blood pressure control, both by modulating renin secretion and by modulating vascular tone directly. Further studies are needed in order to gain a better understanding of the underlying mechanism by which microbiota and microbial metabolites modulate host physiology and their potential implications in health and disease.

AB - New Findings: What is the topic of this review? This review covers recent findings highlighting roles for renal and vascular sensory receptors that modify blood pressure control in response to changes in gut microbial metabolites. What advances does it highlight? This review highlights the novel roles that G-protein-coupled receptor 41 and olfactory receptor 78 play in blood pressure regulation. The gut microbiota have recently been recognized as an important component of host physiology and pathophysiology. Our recent studies have shown that a subset of gut microbial metabolites, known as short-chain fatty acids, act as ligands for host G-protein-coupled receptors (G-protein-coupled receptor 41 and olfactory receptor 78). Short-chain fatty acid-mediated activation of G-protein-coupled receptor 41 and olfactory receptor 78 modulates blood pressure control, both by modulating renin secretion and by modulating vascular tone directly. Further studies are needed in order to gain a better understanding of the underlying mechanism by which microbiota and microbial metabolites modulate host physiology and their potential implications in health and disease.

UR - http://www.scopus.com/inward/record.url?scp=84940468733&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940468733&partnerID=8YFLogxK

U2 - 10.1113/EP085285

DO - 10.1113/EP085285

M3 - Article

C2 - 26238273

AN - SCOPUS:84940468733

JO - Experimental Physiology

JF - Experimental Physiology

SN - 0958-0670

ER -