Olestra is associated with slight reductions in serum carotenoids but does not markedly influence serum fat-soluble vitamin concentrations

Marian L. Neuhouser, Cheryl L. Rock, Alan R. Kristal, Ruth E. Patterson, Dianne Neumark-Sztainer, Lawrence J Cheskin, Mark D. Thornquist

Research output: Contribution to journalArticle

Abstract

Background: The 1996 Food and Drug Administration approval of the fat substitute olestra (sucrose polyester) called for active post-marketing surveillance because preapproval studies showed that olestra may lower circulating concentrations of fat-soluble nutrients such as vitamins and carotenoids. Objective: The objective of the Olestra Post-Marketing Surveillance Study was to examine whether customary consumption of olestra-containing savory snacks was associated with changes in serum fat-soluble vitamin and carotenoid concentrations among free-living persons in geographically and ethnically distinct US cities. Design: Adults (n = 2535) and their children aged 12-17 y (n = 272) in Baltimore, Minneapolis, and San Diego attended clinic visits during which data were collected on diet, savory snack consumption, lifestyle, and anthropometric indexes. Blood samples were drawn to assay carotenoids and vitamins A, D, E, and K. Data and blood samples were collected both before and after the nationwide introduction of olestra. General estimating equations were used in multivariate-adjusted models that examined olestra's association with the specified serum nutrients. Results: Compared with no intake, the top 2 tertiles of olestra use in adults were associated with circulating carotenoid concentrations that were modestly but significantly lower (4.3% to 22.4%). There were no significant associations of olestra with any serum nutrients among adolescents. Conclusions: This active postmarketing surveillance study of a food additive suggests that small decreases in serum fat-soluble nutrients are attributable to olestra use. Although health outcomes were not measured here, it is unlikely that these small changes in nutrient measures would adversely affect health.

Original languageEnglish (US)
Pages (from-to)624-631
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume83
Issue number3
StatePublished - Mar 1 2006

Fingerprint

sucrose polyester
fat soluble vitamins
Carotenoids
blood serum
Vitamins
carotenoids
Fats
Serum
Food
Satureja
nutrients
savory
Snacks
snacks
Marketing
marketing
monitoring
Fat Substitutes
fat substitutes
Drug Approval

Keywords

  • Carotenoids
  • Olestra
  • Postmarketing surveillance
  • Sucrose polyester
  • Vitamin A
  • Vitamin D
  • Vitamin E
  • Vitamin K

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Neuhouser, M. L., Rock, C. L., Kristal, A. R., Patterson, R. E., Neumark-Sztainer, D., Cheskin, L. J., & Thornquist, M. D. (2006). Olestra is associated with slight reductions in serum carotenoids but does not markedly influence serum fat-soluble vitamin concentrations. American Journal of Clinical Nutrition, 83(3), 624-631.

Olestra is associated with slight reductions in serum carotenoids but does not markedly influence serum fat-soluble vitamin concentrations. / Neuhouser, Marian L.; Rock, Cheryl L.; Kristal, Alan R.; Patterson, Ruth E.; Neumark-Sztainer, Dianne; Cheskin, Lawrence J; Thornquist, Mark D.

In: American Journal of Clinical Nutrition, Vol. 83, No. 3, 01.03.2006, p. 624-631.

Research output: Contribution to journalArticle

Neuhouser, ML, Rock, CL, Kristal, AR, Patterson, RE, Neumark-Sztainer, D, Cheskin, LJ & Thornquist, MD 2006, 'Olestra is associated with slight reductions in serum carotenoids but does not markedly influence serum fat-soluble vitamin concentrations', American Journal of Clinical Nutrition, vol. 83, no. 3, pp. 624-631.
Neuhouser, Marian L. ; Rock, Cheryl L. ; Kristal, Alan R. ; Patterson, Ruth E. ; Neumark-Sztainer, Dianne ; Cheskin, Lawrence J ; Thornquist, Mark D. / Olestra is associated with slight reductions in serum carotenoids but does not markedly influence serum fat-soluble vitamin concentrations. In: American Journal of Clinical Nutrition. 2006 ; Vol. 83, No. 3. pp. 624-631.
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abstract = "Background: The 1996 Food and Drug Administration approval of the fat substitute olestra (sucrose polyester) called for active post-marketing surveillance because preapproval studies showed that olestra may lower circulating concentrations of fat-soluble nutrients such as vitamins and carotenoids. Objective: The objective of the Olestra Post-Marketing Surveillance Study was to examine whether customary consumption of olestra-containing savory snacks was associated with changes in serum fat-soluble vitamin and carotenoid concentrations among free-living persons in geographically and ethnically distinct US cities. Design: Adults (n = 2535) and their children aged 12-17 y (n = 272) in Baltimore, Minneapolis, and San Diego attended clinic visits during which data were collected on diet, savory snack consumption, lifestyle, and anthropometric indexes. Blood samples were drawn to assay carotenoids and vitamins A, D, E, and K. Data and blood samples were collected both before and after the nationwide introduction of olestra. General estimating equations were used in multivariate-adjusted models that examined olestra's association with the specified serum nutrients. Results: Compared with no intake, the top 2 tertiles of olestra use in adults were associated with circulating carotenoid concentrations that were modestly but significantly lower (4.3{\%} to 22.4{\%}). There were no significant associations of olestra with any serum nutrients among adolescents. Conclusions: This active postmarketing surveillance study of a food additive suggests that small decreases in serum fat-soluble nutrients are attributable to olestra use. Although health outcomes were not measured here, it is unlikely that these small changes in nutrient measures would adversely affect health.",
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