Oleander poisoning: Treatment with digoxin-specific fab antibody fragments

George M. Shumaik, Albert W. Wu, Andrew C. Ping

Research output: Contribution to journalArticlepeer-review


A 37-year-old man presented two hours after the ingestion of "a handful" of oleander leaves (probably Nerium oleander) in a suicide attempt. Cardiotoxicity was evidenced by the presence of bradycardia (rate, 30 to 45) with sinoatrial nodal arrest and junctional escape consistent with a cardiac glycoside effect. The patient was treated empirically with a single dose of five vials (200 mg) of digoxin-specific Fab antibody fragments (Digibind®). The pretreatment digoxin level was 1.5 ng/mL. After treatment, the patient's rhythm stabilized with residual sinus bradycardia (rate, 56). The patient recovered uneventfully and was discharged on the fifth hospital day to inpatient psychiatric care.

Original languageEnglish (US)
Pages (from-to)732-735
Number of pages4
JournalAnnals of emergency medicine
Issue number7
StatePublished - Jul 1988
Externally publishedYes


  • Fab antibody fragments, poisoning, oleander
  • poisoning, oleander

ASJC Scopus subject areas

  • Emergency Medicine


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