Older women with diabetes have an increased risk of fracture

A prospective study

Ann V. Schwartz, Deborah E. Sellmeyer, Kristine E. Ensrud, Jane A. Cauley, Holly K. Tabor, Pamela J. Schreiner, Sophie A. Jamal, Dennis M. Black, Steven R. Cummings

Research output: Contribution to journalArticle

Abstract

To determine whether type 2 diabetes is associated with fracture in older women, we analyzed data from 9654 women, age 65 yr or older, in the Study of Osteoporotic Fractures. Diabetes with age at onset 40 yr or older was reported by 657 women, of whom 106 used insulin. A total of 2624 women experienced at least one nonvertebral fracture during an average follow-up of 9.4 yr, and 388 had at least one vertebral fracture during an average interval of 3.7 yr. Although diabetes was associated with higher bone mineral density, it was also associated with a higher risk of specific fractures. Compared with nondiabetics, women with diabetes who were not using insulin had an increased risk of hip [relative risk (RR), 1.82; 95% confidence interval (CI), 1.24-2.69] and proximal humerus (RR, 1.94; 95% CI, 1.24-3.02) fractures in multivariate models controlling for age, body mass index, bone density, and other factors associated with fractures and diabetes. Insulin-treated diabetics had more than double the risk of foot (multivariate adjusted RR, 2.66; 95% CI, 1.18-6.02) fractures compared with nondiabetics. This study indicates that diabetes is a risk factor for hip, proximal humerus, and foot fractures among older women, suggesting that fracture prevention efforts should be a consideration in the treatment of diabetes.

Original languageEnglish (US)
Pages (from-to)32-38
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume86
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Medical problems
Prospective Studies
Humerus
Confidence Intervals
Insulin
Bone Density
Hip
Foot
Osteoporotic Fractures
Bone
Age of Onset
Type 2 Diabetes Mellitus
Body Mass Index
Minerals

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Schwartz, A. V., Sellmeyer, D. E., Ensrud, K. E., Cauley, J. A., Tabor, H. K., Schreiner, P. J., ... Cummings, S. R. (2001). Older women with diabetes have an increased risk of fracture: A prospective study. Journal of Clinical Endocrinology and Metabolism, 86(1), 32-38. https://doi.org/10.1210/jc.86.1.32

Older women with diabetes have an increased risk of fracture : A prospective study. / Schwartz, Ann V.; Sellmeyer, Deborah E.; Ensrud, Kristine E.; Cauley, Jane A.; Tabor, Holly K.; Schreiner, Pamela J.; Jamal, Sophie A.; Black, Dennis M.; Cummings, Steven R.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 86, No. 1, 2001, p. 32-38.

Research output: Contribution to journalArticle

Schwartz, AV, Sellmeyer, DE, Ensrud, KE, Cauley, JA, Tabor, HK, Schreiner, PJ, Jamal, SA, Black, DM & Cummings, SR 2001, 'Older women with diabetes have an increased risk of fracture: A prospective study', Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 1, pp. 32-38. https://doi.org/10.1210/jc.86.1.32
Schwartz, Ann V. ; Sellmeyer, Deborah E. ; Ensrud, Kristine E. ; Cauley, Jane A. ; Tabor, Holly K. ; Schreiner, Pamela J. ; Jamal, Sophie A. ; Black, Dennis M. ; Cummings, Steven R. / Older women with diabetes have an increased risk of fracture : A prospective study. In: Journal of Clinical Endocrinology and Metabolism. 2001 ; Vol. 86, No. 1. pp. 32-38.
@article{de4a32ed650a4a999b025e068c1d3c83,
title = "Older women with diabetes have an increased risk of fracture: A prospective study",
abstract = "To determine whether type 2 diabetes is associated with fracture in older women, we analyzed data from 9654 women, age 65 yr or older, in the Study of Osteoporotic Fractures. Diabetes with age at onset 40 yr or older was reported by 657 women, of whom 106 used insulin. A total of 2624 women experienced at least one nonvertebral fracture during an average follow-up of 9.4 yr, and 388 had at least one vertebral fracture during an average interval of 3.7 yr. Although diabetes was associated with higher bone mineral density, it was also associated with a higher risk of specific fractures. Compared with nondiabetics, women with diabetes who were not using insulin had an increased risk of hip [relative risk (RR), 1.82; 95{\%} confidence interval (CI), 1.24-2.69] and proximal humerus (RR, 1.94; 95{\%} CI, 1.24-3.02) fractures in multivariate models controlling for age, body mass index, bone density, and other factors associated with fractures and diabetes. Insulin-treated diabetics had more than double the risk of foot (multivariate adjusted RR, 2.66; 95{\%} CI, 1.18-6.02) fractures compared with nondiabetics. This study indicates that diabetes is a risk factor for hip, proximal humerus, and foot fractures among older women, suggesting that fracture prevention efforts should be a consideration in the treatment of diabetes.",
author = "Schwartz, {Ann V.} and Sellmeyer, {Deborah E.} and Ensrud, {Kristine E.} and Cauley, {Jane A.} and Tabor, {Holly K.} and Schreiner, {Pamela J.} and Jamal, {Sophie A.} and Black, {Dennis M.} and Cummings, {Steven R.}",
year = "2001",
doi = "10.1210/jc.86.1.32",
language = "English (US)",
volume = "86",
pages = "32--38",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "1",

}

TY - JOUR

T1 - Older women with diabetes have an increased risk of fracture

T2 - A prospective study

AU - Schwartz, Ann V.

AU - Sellmeyer, Deborah E.

AU - Ensrud, Kristine E.

AU - Cauley, Jane A.

AU - Tabor, Holly K.

AU - Schreiner, Pamela J.

AU - Jamal, Sophie A.

AU - Black, Dennis M.

AU - Cummings, Steven R.

PY - 2001

Y1 - 2001

N2 - To determine whether type 2 diabetes is associated with fracture in older women, we analyzed data from 9654 women, age 65 yr or older, in the Study of Osteoporotic Fractures. Diabetes with age at onset 40 yr or older was reported by 657 women, of whom 106 used insulin. A total of 2624 women experienced at least one nonvertebral fracture during an average follow-up of 9.4 yr, and 388 had at least one vertebral fracture during an average interval of 3.7 yr. Although diabetes was associated with higher bone mineral density, it was also associated with a higher risk of specific fractures. Compared with nondiabetics, women with diabetes who were not using insulin had an increased risk of hip [relative risk (RR), 1.82; 95% confidence interval (CI), 1.24-2.69] and proximal humerus (RR, 1.94; 95% CI, 1.24-3.02) fractures in multivariate models controlling for age, body mass index, bone density, and other factors associated with fractures and diabetes. Insulin-treated diabetics had more than double the risk of foot (multivariate adjusted RR, 2.66; 95% CI, 1.18-6.02) fractures compared with nondiabetics. This study indicates that diabetes is a risk factor for hip, proximal humerus, and foot fractures among older women, suggesting that fracture prevention efforts should be a consideration in the treatment of diabetes.

AB - To determine whether type 2 diabetes is associated with fracture in older women, we analyzed data from 9654 women, age 65 yr or older, in the Study of Osteoporotic Fractures. Diabetes with age at onset 40 yr or older was reported by 657 women, of whom 106 used insulin. A total of 2624 women experienced at least one nonvertebral fracture during an average follow-up of 9.4 yr, and 388 had at least one vertebral fracture during an average interval of 3.7 yr. Although diabetes was associated with higher bone mineral density, it was also associated with a higher risk of specific fractures. Compared with nondiabetics, women with diabetes who were not using insulin had an increased risk of hip [relative risk (RR), 1.82; 95% confidence interval (CI), 1.24-2.69] and proximal humerus (RR, 1.94; 95% CI, 1.24-3.02) fractures in multivariate models controlling for age, body mass index, bone density, and other factors associated with fractures and diabetes. Insulin-treated diabetics had more than double the risk of foot (multivariate adjusted RR, 2.66; 95% CI, 1.18-6.02) fractures compared with nondiabetics. This study indicates that diabetes is a risk factor for hip, proximal humerus, and foot fractures among older women, suggesting that fracture prevention efforts should be a consideration in the treatment of diabetes.

UR - http://www.scopus.com/inward/record.url?scp=0035143770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035143770&partnerID=8YFLogxK

U2 - 10.1210/jc.86.1.32

DO - 10.1210/jc.86.1.32

M3 - Article

VL - 86

SP - 32

EP - 38

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 1

ER -