Older dopaminergic neurons do not recover from the effects of MPTP

George Ricaurte, L. E. DeLanney, I. Irwin, J. W. Langston

Research output: Contribution to journalArticle

Abstract

Recent studies have shown that dopaminergic neurons in young mature mice recover fully from toxic injury induced by MPTP. The aim of the present study was to assess whether or not older dopaminergic neurons were capable of similar recovery. We now report that older dopaminergic neurons do not recover from the effects of MPTP. This suggests that with age, neurons in the nigrostriatal system begin to lose their regenerative capacity. This phenomenon could underlie the process of neuronal degeneration known to occur in a number of age-related diseases, including Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)97-99
Number of pages3
JournalNeuropharmacology
Volume26
Issue number1
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Dopaminergic Neurons
Poisons
Parkinson Disease
Neurons
Wounds and Injuries

Keywords

  • Aging
  • Dopamine
  • Parkinson's Disease
  • Recovery MPTP
  • Substantia Nigra

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Older dopaminergic neurons do not recover from the effects of MPTP. / Ricaurte, George; DeLanney, L. E.; Irwin, I.; Langston, J. W.

In: Neuropharmacology, Vol. 26, No. 1, 1987, p. 97-99.

Research output: Contribution to journalArticle

Ricaurte, George ; DeLanney, L. E. ; Irwin, I. ; Langston, J. W. / Older dopaminergic neurons do not recover from the effects of MPTP. In: Neuropharmacology. 1987 ; Vol. 26, No. 1. pp. 97-99.
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