OKT4 epitope deficiency in a patient with acute myeloblastic leukemia

Shinsaku Imashuku, Shinjiro Todo, Yoshihito Morioka, Tohru Sugimoto, Noriko Esumi, Kentaro Tsunamoto, Yoshitaka Shimizu, Fumihiro Fujiwara

Research output: Contribution to journalArticle

Abstract

The association of OKT4 epitope deficiency and acute myloblastic leukemia (Ml by FAB) in a 12-year-old girl is reported. The patient’s peripheral lymphocytes lacked the antigen identified by the OKT4 monoclonal antibody, but showed normal OKT4A and Leu-3a reactivity. Functional studies of the lymphocytes revealed normal responses to mitogens, but slightly reduced helper T cell function. The patient responded well to antileukemia chemotherapy and has been in remission for 30 months. The possible link between OKT4 epitope deficiency and the pathogenesis of AML is discussed.

Original languageEnglish (US)
Pages (from-to)242
Number of pages1
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume9
Issue number3
StatePublished - 1987
Externally publishedYes

Fingerprint

Acute Myeloid Leukemia
Epitopes
Lymphocytes
Helper-Inducer T-Lymphocytes
Mitogens
Leukemia
Monoclonal Antibodies
Antigens
Drug Therapy
OKT4A monoclonal antibody

Keywords

  • Acute myeloblastic leukemia
  • OKT4 epitope deficiency

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

Cite this

Imashuku, S., Todo, S., Morioka, Y., Sugimoto, T., Esumi, N., Tsunamoto, K., ... Fujiwara, F. (1987). OKT4 epitope deficiency in a patient with acute myeloblastic leukemia. American Journal of Pediatric Hematology/Oncology, 9(3), 242.

OKT4 epitope deficiency in a patient with acute myeloblastic leukemia. / Imashuku, Shinsaku; Todo, Shinjiro; Morioka, Yoshihito; Sugimoto, Tohru; Esumi, Noriko; Tsunamoto, Kentaro; Shimizu, Yoshitaka; Fujiwara, Fumihiro.

In: American Journal of Pediatric Hematology/Oncology, Vol. 9, No. 3, 1987, p. 242.

Research output: Contribution to journalArticle

Imashuku, S, Todo, S, Morioka, Y, Sugimoto, T, Esumi, N, Tsunamoto, K, Shimizu, Y & Fujiwara, F 1987, 'OKT4 epitope deficiency in a patient with acute myeloblastic leukemia', American Journal of Pediatric Hematology/Oncology, vol. 9, no. 3, pp. 242.
Imashuku, Shinsaku ; Todo, Shinjiro ; Morioka, Yoshihito ; Sugimoto, Tohru ; Esumi, Noriko ; Tsunamoto, Kentaro ; Shimizu, Yoshitaka ; Fujiwara, Fumihiro. / OKT4 epitope deficiency in a patient with acute myeloblastic leukemia. In: American Journal of Pediatric Hematology/Oncology. 1987 ; Vol. 9, No. 3. pp. 242.
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