Abstract
The association of OKT4 epitope deficiency and acute myloblastic leukemia (Ml by FAB) in a 12-year-old girl is reported. The patient’s peripheral lymphocytes lacked the antigen identified by the OKT4 monoclonal antibody, but showed normal OKT4A and Leu-3a reactivity. Functional studies of the lymphocytes revealed normal responses to mitogens, but slightly reduced helper T cell function. The patient responded well to antileukemia chemotherapy and has been in remission for 30 months. The possible link between OKT4 epitope deficiency and the pathogenesis of AML is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 242 |
| Number of pages | 1 |
| Journal | American Journal of Pediatric Hematology/Oncology |
| Volume | 9 |
| Issue number | 3 |
| State | Published - 1987 |
| Externally published | Yes |
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Keywords
- Acute myeloblastic leukemia
- OKT4 epitope deficiency
ASJC Scopus subject areas
- Hematology
- Oncology
- Pediatrics, Perinatology, and Child Health
Cite this
OKT4 epitope deficiency in a patient with acute myeloblastic leukemia. / Imashuku, Shinsaku; Todo, Shinjiro; Morioka, Yoshihito; Sugimoto, Tohru; Esumi, Noriko; Tsunamoto, Kentaro; Shimizu, Yoshitaka; Fujiwara, Fumihiro.
In: American Journal of Pediatric Hematology/Oncology, Vol. 9, No. 3, 1987, p. 242.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - OKT4 epitope deficiency in a patient with acute myeloblastic leukemia
AU - Imashuku, Shinsaku
AU - Todo, Shinjiro
AU - Morioka, Yoshihito
AU - Sugimoto, Tohru
AU - Esumi, Noriko
AU - Tsunamoto, Kentaro
AU - Shimizu, Yoshitaka
AU - Fujiwara, Fumihiro
PY - 1987
Y1 - 1987
N2 - The association of OKT4 epitope deficiency and acute myloblastic leukemia (Ml by FAB) in a 12-year-old girl is reported. The patient’s peripheral lymphocytes lacked the antigen identified by the OKT4 monoclonal antibody, but showed normal OKT4A and Leu-3a reactivity. Functional studies of the lymphocytes revealed normal responses to mitogens, but slightly reduced helper T cell function. The patient responded well to antileukemia chemotherapy and has been in remission for 30 months. The possible link between OKT4 epitope deficiency and the pathogenesis of AML is discussed.
AB - The association of OKT4 epitope deficiency and acute myloblastic leukemia (Ml by FAB) in a 12-year-old girl is reported. The patient’s peripheral lymphocytes lacked the antigen identified by the OKT4 monoclonal antibody, but showed normal OKT4A and Leu-3a reactivity. Functional studies of the lymphocytes revealed normal responses to mitogens, but slightly reduced helper T cell function. The patient responded well to antileukemia chemotherapy and has been in remission for 30 months. The possible link between OKT4 epitope deficiency and the pathogenesis of AML is discussed.
KW - Acute myeloblastic leukemia
KW - OKT4 epitope deficiency
UR - http://www.scopus.com/inward/record.url?scp=0023409142&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023409142&partnerID=8YFLogxK
M3 - Article
C2 - 2960246
AN - SCOPUS:0023409142
VL - 9
SP - 242
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
SN - 1077-4114
IS - 3
ER -