OKT4 epitope deficiency in a patient with acute myeloblastic leukemia

Shinsaku Imashuku; Shinjiro Todo; Yoshihito Morioka; Tohru Sugimoto; Noriko Esumi; Kentaro Tsunamoto; Yoshitaka Shimizu; Fumihiro Fujiwara

OKT4 epitope deficiency in a patient with acute myeloblastic leukemia

Shinsaku Imashuku, Shinjiro Todo, Yoshihito Morioka, Tohru Sugimoto, Noriko Esumi, Kentaro Tsunamoto, Yoshitaka Shimizu, Fumihiro Fujiwara

Research output: Contribution to journal › Article › peer-review

Abstract

The association of OKT4 epitope deficiency and acute myloblastic leukemia (Ml by FAB) in a 12-year-old girl is reported. The patient’s peripheral lymphocytes lacked the antigen identified by the OKT4 monoclonal antibody, but showed normal OKT4A and Leu-3a reactivity. Functional studies of the lymphocytes revealed normal responses to mitogens, but slightly reduced helper T cell function. The patient responded well to antileukemia chemotherapy and has been in remission for 30 months. The possible link between OKT4 epitope deficiency and the pathogenesis of AML is discussed.

Original language	English (US)
Number of pages	1
Journal	American Journal of Pediatric Hematology/Oncology
Volume	9
Issue number	3
State	Published - Jan 1 1987
Externally published	Yes

Keywords

Acute myeloblastic leukemia
OKT4 epitope deficiency

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Cite this

OKT4 epitope deficiency in a patient with acute myeloblastic leukemia. / Imashuku, Shinsaku; Todo, Shinjiro; Morioka, Yoshihito; Sugimoto, Tohru; Esumi, Noriko; Tsunamoto, Kentaro; Shimizu, Yoshitaka; Fujiwara, Fumihiro.

In: American Journal of Pediatric Hematology/Oncology, Vol. 9, No. 3, 01.01.1987.

Research output: Contribution to journal › Article › peer-review

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abstract = "The association of OKT4 epitope deficiency and acute myloblastic leukemia (Ml by FAB) in a 12-year-old girl is reported. The patient{\textquoteright}s peripheral lymphocytes lacked the antigen identified by the OKT4 monoclonal antibody, but showed normal OKT4A and Leu-3a reactivity. Functional studies of the lymphocytes revealed normal responses to mitogens, but slightly reduced helper T cell function. The patient responded well to antileukemia chemotherapy and has been in remission for 30 months. The possible link between OKT4 epitope deficiency and the pathogenesis of AML is discussed.",

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AU - Imashuku, Shinsaku

AU - Todo, Shinjiro

AU - Morioka, Yoshihito

AU - Sugimoto, Tohru

AU - Esumi, Noriko

AU - Tsunamoto, Kentaro

AU - Shimizu, Yoshitaka

AU - Fujiwara, Fumihiro

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N2 - The association of OKT4 epitope deficiency and acute myloblastic leukemia (Ml by FAB) in a 12-year-old girl is reported. The patient’s peripheral lymphocytes lacked the antigen identified by the OKT4 monoclonal antibody, but showed normal OKT4A and Leu-3a reactivity. Functional studies of the lymphocytes revealed normal responses to mitogens, but slightly reduced helper T cell function. The patient responded well to antileukemia chemotherapy and has been in remission for 30 months. The possible link between OKT4 epitope deficiency and the pathogenesis of AML is discussed.

AB - The association of OKT4 epitope deficiency and acute myloblastic leukemia (Ml by FAB) in a 12-year-old girl is reported. The patient’s peripheral lymphocytes lacked the antigen identified by the OKT4 monoclonal antibody, but showed normal OKT4A and Leu-3a reactivity. Functional studies of the lymphocytes revealed normal responses to mitogens, but slightly reduced helper T cell function. The patient responded well to antileukemia chemotherapy and has been in remission for 30 months. The possible link between OKT4 epitope deficiency and the pathogenesis of AML is discussed.

KW - Acute myeloblastic leukemia

KW - OKT4 epitope deficiency

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OKT4 epitope deficiency in a patient with acute myeloblastic leukemia

Abstract

Keywords

ASJC Scopus subject areas

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