Off-clamp robot-assisted partial nephrectomy preserves renal function

A multi-institutional propensity score analysis

Bartosz F. Kaczmarek, Youssef S. Tanagho, Shahab P. Hillyer, Jeffrey K. Mullins, Mireya Diaz, Quoc Dien Trinh, Sam B. Bhayani, Mohamad E Allaf, Michael D. Stifelman, Jihad H. Kaouk, Craig G. Rogers

Research output: Contribution to journalArticle

Abstract

Background: Ongoing efforts are focused on minimizing or eliminating renal ischemia during robot-assisted partial nephrectomy (RPN). Although various techniques allowing the elimination of renal hilar clamping have been described, large multi-institutional studies assessing perioperative and functional outcomes of this approach are lacking. Objective: To evaluate perioperative and functional outcomes of RPN without hilar clamping and to assess comparative effectiveness relative to clamped RPN. Design, setting, and participants: A multi-institutional data analysis of prospectively collected records of 886 RPNs performed by high-volume surgeons across five academic institutions between 2007 and 2011 was carried out. A total of 66 patients who underwent RPN without hilar clamping were identified. After the exclusion of 17 patients, perioperative results of 49 patients were compared against propensity score matched clamped controls. Intervention: RPN without hilar clamping. Outcome measurements and statistical analysis: Descriptive statistics and propensity score matching. Results and limitations: Patients undergoing off-clamp RPN had a mean tumor size of 2.5 cm (standard deviation [SD]: ±2.1) and a mean RENAL nephrometry score of 5.3 (SD: ±1.5). The mean preoperative estimated glomerular filtration rate (eGFR) was 81 (SD: ±29). The mean estimated blood loss (EBL) was 210 ml (SD: ±212), and the mean operative time was 155 min (SD: ±46). No Clavien 3-5 complications were recorded. The mean postoperative change in eGFR was 3% at first follow-up (1-3 mo), and no patient required postoperative dialysis. The positive surgical margin rate was 3% (n = 2), with no disease recurrence reported at a mean follow-up of 21 mo. In propensity score matched analyses, the off-clamp RPN patients had a significantly shorter mean operative time (156 min compared with 185 min, p <0.001), a higher EBL (228 ml compared with 157 ml, p = 0.009), and a smaller decrease in eGFR (2% compared with -6%, p = 0.008). The retrospective analysis was the main limitation of this study. Conclusions: With appropriately selected patients and adequate surgeon experience, off-clamp RPN is safe and feasible. Off-clamp RPN was associated with higher EBL, shorter operative times, and smaller decrease in renal function.

Original languageEnglish (US)
Pages (from-to)988-993
Number of pages6
JournalEuropean Urology
Volume64
Issue number6
DOIs
StatePublished - Dec 2013

Fingerprint

Propensity Score
Nephrectomy
Kidney
Constriction
Operative Time
Glomerular Filtration Rate
Dialysis
Ischemia
Recurrence

Keywords

  • Nephron-sparing surgery
  • No clamp
  • Off-clamp
  • Robot-assisted partial nephrectomy
  • Robotic partial nephrectomy
  • Warm ischemia time
  • Zero ischemia

ASJC Scopus subject areas

  • Urology

Cite this

Kaczmarek, B. F., Tanagho, Y. S., Hillyer, S. P., Mullins, J. K., Diaz, M., Trinh, Q. D., ... Rogers, C. G. (2013). Off-clamp robot-assisted partial nephrectomy preserves renal function: A multi-institutional propensity score analysis. European Urology, 64(6), 988-993. https://doi.org/10.1016/j.eururo.2012.10.009

Off-clamp robot-assisted partial nephrectomy preserves renal function : A multi-institutional propensity score analysis. / Kaczmarek, Bartosz F.; Tanagho, Youssef S.; Hillyer, Shahab P.; Mullins, Jeffrey K.; Diaz, Mireya; Trinh, Quoc Dien; Bhayani, Sam B.; Allaf, Mohamad E; Stifelman, Michael D.; Kaouk, Jihad H.; Rogers, Craig G.

In: European Urology, Vol. 64, No. 6, 12.2013, p. 988-993.

Research output: Contribution to journalArticle

Kaczmarek, BF, Tanagho, YS, Hillyer, SP, Mullins, JK, Diaz, M, Trinh, QD, Bhayani, SB, Allaf, ME, Stifelman, MD, Kaouk, JH & Rogers, CG 2013, 'Off-clamp robot-assisted partial nephrectomy preserves renal function: A multi-institutional propensity score analysis', European Urology, vol. 64, no. 6, pp. 988-993. https://doi.org/10.1016/j.eururo.2012.10.009
Kaczmarek, Bartosz F. ; Tanagho, Youssef S. ; Hillyer, Shahab P. ; Mullins, Jeffrey K. ; Diaz, Mireya ; Trinh, Quoc Dien ; Bhayani, Sam B. ; Allaf, Mohamad E ; Stifelman, Michael D. ; Kaouk, Jihad H. ; Rogers, Craig G. / Off-clamp robot-assisted partial nephrectomy preserves renal function : A multi-institutional propensity score analysis. In: European Urology. 2013 ; Vol. 64, No. 6. pp. 988-993.
@article{8f013c04b1fe4ee1bc23012feac1bb54,
title = "Off-clamp robot-assisted partial nephrectomy preserves renal function: A multi-institutional propensity score analysis",
abstract = "Background: Ongoing efforts are focused on minimizing or eliminating renal ischemia during robot-assisted partial nephrectomy (RPN). Although various techniques allowing the elimination of renal hilar clamping have been described, large multi-institutional studies assessing perioperative and functional outcomes of this approach are lacking. Objective: To evaluate perioperative and functional outcomes of RPN without hilar clamping and to assess comparative effectiveness relative to clamped RPN. Design, setting, and participants: A multi-institutional data analysis of prospectively collected records of 886 RPNs performed by high-volume surgeons across five academic institutions between 2007 and 2011 was carried out. A total of 66 patients who underwent RPN without hilar clamping were identified. After the exclusion of 17 patients, perioperative results of 49 patients were compared against propensity score matched clamped controls. Intervention: RPN without hilar clamping. Outcome measurements and statistical analysis: Descriptive statistics and propensity score matching. Results and limitations: Patients undergoing off-clamp RPN had a mean tumor size of 2.5 cm (standard deviation [SD]: ±2.1) and a mean RENAL nephrometry score of 5.3 (SD: ±1.5). The mean preoperative estimated glomerular filtration rate (eGFR) was 81 (SD: ±29). The mean estimated blood loss (EBL) was 210 ml (SD: ±212), and the mean operative time was 155 min (SD: ±46). No Clavien 3-5 complications were recorded. The mean postoperative change in eGFR was 3{\%} at first follow-up (1-3 mo), and no patient required postoperative dialysis. The positive surgical margin rate was 3{\%} (n = 2), with no disease recurrence reported at a mean follow-up of 21 mo. In propensity score matched analyses, the off-clamp RPN patients had a significantly shorter mean operative time (156 min compared with 185 min, p <0.001), a higher EBL (228 ml compared with 157 ml, p = 0.009), and a smaller decrease in eGFR (2{\%} compared with -6{\%}, p = 0.008). The retrospective analysis was the main limitation of this study. Conclusions: With appropriately selected patients and adequate surgeon experience, off-clamp RPN is safe and feasible. Off-clamp RPN was associated with higher EBL, shorter operative times, and smaller decrease in renal function.",
keywords = "Nephron-sparing surgery, No clamp, Off-clamp, Robot-assisted partial nephrectomy, Robotic partial nephrectomy, Warm ischemia time, Zero ischemia",
author = "Kaczmarek, {Bartosz F.} and Tanagho, {Youssef S.} and Hillyer, {Shahab P.} and Mullins, {Jeffrey K.} and Mireya Diaz and Trinh, {Quoc Dien} and Bhayani, {Sam B.} and Allaf, {Mohamad E} and Stifelman, {Michael D.} and Kaouk, {Jihad H.} and Rogers, {Craig G.}",
year = "2013",
month = "12",
doi = "10.1016/j.eururo.2012.10.009",
language = "English (US)",
volume = "64",
pages = "988--993",
journal = "European Urology",
issn = "0302-2838",
publisher = "Elsevier",
number = "6",

}

TY - JOUR

T1 - Off-clamp robot-assisted partial nephrectomy preserves renal function

T2 - A multi-institutional propensity score analysis

AU - Kaczmarek, Bartosz F.

AU - Tanagho, Youssef S.

AU - Hillyer, Shahab P.

AU - Mullins, Jeffrey K.

AU - Diaz, Mireya

AU - Trinh, Quoc Dien

AU - Bhayani, Sam B.

AU - Allaf, Mohamad E

AU - Stifelman, Michael D.

AU - Kaouk, Jihad H.

AU - Rogers, Craig G.

PY - 2013/12

Y1 - 2013/12

N2 - Background: Ongoing efforts are focused on minimizing or eliminating renal ischemia during robot-assisted partial nephrectomy (RPN). Although various techniques allowing the elimination of renal hilar clamping have been described, large multi-institutional studies assessing perioperative and functional outcomes of this approach are lacking. Objective: To evaluate perioperative and functional outcomes of RPN without hilar clamping and to assess comparative effectiveness relative to clamped RPN. Design, setting, and participants: A multi-institutional data analysis of prospectively collected records of 886 RPNs performed by high-volume surgeons across five academic institutions between 2007 and 2011 was carried out. A total of 66 patients who underwent RPN without hilar clamping were identified. After the exclusion of 17 patients, perioperative results of 49 patients were compared against propensity score matched clamped controls. Intervention: RPN without hilar clamping. Outcome measurements and statistical analysis: Descriptive statistics and propensity score matching. Results and limitations: Patients undergoing off-clamp RPN had a mean tumor size of 2.5 cm (standard deviation [SD]: ±2.1) and a mean RENAL nephrometry score of 5.3 (SD: ±1.5). The mean preoperative estimated glomerular filtration rate (eGFR) was 81 (SD: ±29). The mean estimated blood loss (EBL) was 210 ml (SD: ±212), and the mean operative time was 155 min (SD: ±46). No Clavien 3-5 complications were recorded. The mean postoperative change in eGFR was 3% at first follow-up (1-3 mo), and no patient required postoperative dialysis. The positive surgical margin rate was 3% (n = 2), with no disease recurrence reported at a mean follow-up of 21 mo. In propensity score matched analyses, the off-clamp RPN patients had a significantly shorter mean operative time (156 min compared with 185 min, p <0.001), a higher EBL (228 ml compared with 157 ml, p = 0.009), and a smaller decrease in eGFR (2% compared with -6%, p = 0.008). The retrospective analysis was the main limitation of this study. Conclusions: With appropriately selected patients and adequate surgeon experience, off-clamp RPN is safe and feasible. Off-clamp RPN was associated with higher EBL, shorter operative times, and smaller decrease in renal function.

AB - Background: Ongoing efforts are focused on minimizing or eliminating renal ischemia during robot-assisted partial nephrectomy (RPN). Although various techniques allowing the elimination of renal hilar clamping have been described, large multi-institutional studies assessing perioperative and functional outcomes of this approach are lacking. Objective: To evaluate perioperative and functional outcomes of RPN without hilar clamping and to assess comparative effectiveness relative to clamped RPN. Design, setting, and participants: A multi-institutional data analysis of prospectively collected records of 886 RPNs performed by high-volume surgeons across five academic institutions between 2007 and 2011 was carried out. A total of 66 patients who underwent RPN without hilar clamping were identified. After the exclusion of 17 patients, perioperative results of 49 patients were compared against propensity score matched clamped controls. Intervention: RPN without hilar clamping. Outcome measurements and statistical analysis: Descriptive statistics and propensity score matching. Results and limitations: Patients undergoing off-clamp RPN had a mean tumor size of 2.5 cm (standard deviation [SD]: ±2.1) and a mean RENAL nephrometry score of 5.3 (SD: ±1.5). The mean preoperative estimated glomerular filtration rate (eGFR) was 81 (SD: ±29). The mean estimated blood loss (EBL) was 210 ml (SD: ±212), and the mean operative time was 155 min (SD: ±46). No Clavien 3-5 complications were recorded. The mean postoperative change in eGFR was 3% at first follow-up (1-3 mo), and no patient required postoperative dialysis. The positive surgical margin rate was 3% (n = 2), with no disease recurrence reported at a mean follow-up of 21 mo. In propensity score matched analyses, the off-clamp RPN patients had a significantly shorter mean operative time (156 min compared with 185 min, p <0.001), a higher EBL (228 ml compared with 157 ml, p = 0.009), and a smaller decrease in eGFR (2% compared with -6%, p = 0.008). The retrospective analysis was the main limitation of this study. Conclusions: With appropriately selected patients and adequate surgeon experience, off-clamp RPN is safe and feasible. Off-clamp RPN was associated with higher EBL, shorter operative times, and smaller decrease in renal function.

KW - Nephron-sparing surgery

KW - No clamp

KW - Off-clamp

KW - Robot-assisted partial nephrectomy

KW - Robotic partial nephrectomy

KW - Warm ischemia time

KW - Zero ischemia

UR - http://www.scopus.com/inward/record.url?scp=84887405687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887405687&partnerID=8YFLogxK

U2 - 10.1016/j.eururo.2012.10.009

DO - 10.1016/j.eururo.2012.10.009

M3 - Article

VL - 64

SP - 988

EP - 993

JO - European Urology

JF - European Urology

SN - 0302-2838

IS - 6

ER -