Off-axis integrated cavity output spectroscopy with a mid-infrared interband cascade laser for real-time breath ethane measurements

Krishnan R. Parameswaran, David I. Rosen, Mark G. Allen, Alan M. Ganz, Terence H. Risby

Research output: Contribution to journalArticlepeer-review

Abstract

Cavity-enhanced tunable diode laser absorption spectroscopy is an attractive method for measuring small concentrations of gaseous species. Ethane is a breath biomarker of lipid peroxidation initiated by reactive oxygen species. A noninvasive means of quickly quantifying oxidative stress status has the potential for broad clinical application. We present a simple, compact system using off-axis integrated cavity output spectroscopy with an interband cascade laser and demonstrate its use in real-time measurements of breath ethane. We demonstrate a detection sensitivity of 0.48ppb/Hz1/2.

Original languageEnglish (US)
Pages (from-to)B73-B79
JournalApplied Optics
Volume48
Issue number4
DOIs
StatePublished - Feb 1 2009

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering

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