Odorant-binding protein: Odorant transport function in the vertebrate nasal epithelium

Jonathan Pevsner; Solomon H. Snyder

doi:10.1093/chemse/15.2.217

Odorant-binding protein: Odorant transport function in the vertebrate nasal epithelium

Jonathan Pevsner, Solomon H. Snyder

Research output: Contribution to journal › Article › peer-review

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Abstract

The odorant-binding protein (OBP) is an abundant, soluble protein of subunit molecular mass 18 000 daltons in the rat, synthesized in the lateral nasal gland, from where it is secreted into nasal mucus. The protein binds odorants of various structural classes such as pyrazines, terpenoids and aromatics. Molecular cloning and sequence analysis of several cDNAs for rat OBP indicate that the protein is significantly homologous to α_2u-globulin and a superfamily of proteins that are believed to transport hydrophobic ligands. These data suggest that OBP transports odorants in mucus, possibly by a mechanism of facilitated diffusion. The proposed transport of odorants by OBP is analogous to the transport of molecular oxygen by hemoglobin.

Original language	English (US)
Pages (from-to)	217-222
Number of pages	6
Journal	Chemical Senses
Volume	15
Issue number	2
DOIs	https://doi.org/10.1093/chemse/15.2.217
State	Published - Apr 1990

ASJC Scopus subject areas

Physiology
Sensory Systems
Physiology (medical)
Behavioral Neuroscience

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title = "Odorant-binding protein: Odorant transport function in the vertebrate nasal epithelium",

abstract = "The odorant-binding protein (OBP) is an abundant, soluble protein of subunit molecular mass 18 000 daltons in the rat, synthesized in the lateral nasal gland, from where it is secreted into nasal mucus. The protein binds odorants of various structural classes such as pyrazines, terpenoids and aromatics. Molecular cloning and sequence analysis of several cDNAs for rat OBP indicate that the protein is significantly homologous to α2u-globulin and a superfamily of proteins that are believed to transport hydrophobic ligands. These data suggest that OBP transports odorants in mucus, possibly by a mechanism of facilitated diffusion. The proposed transport of odorants by OBP is analogous to the transport of molecular oxygen by hemoglobin.",

author = "Jonathan Pevsner and Snyder, {Solomon H.}",

note = "Funding Information: We thank Dr Peter Maloney for valuable discussions on facilitated diffusion, and N.Varg for manuscript preparation. This work was supported by U.S. P.H.S. grant DA-00266, from International Flavors and Fragrances, Union Beach, NJ and Research Scientist Award DA-00074 (to S.H.S.). Copyright: Copyright 2010 Elsevier B.V., All rights reserved.",

year = "1990",

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AU - Snyder, Solomon H.

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PY - 1990/4

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N2 - The odorant-binding protein (OBP) is an abundant, soluble protein of subunit molecular mass 18 000 daltons in the rat, synthesized in the lateral nasal gland, from where it is secreted into nasal mucus. The protein binds odorants of various structural classes such as pyrazines, terpenoids and aromatics. Molecular cloning and sequence analysis of several cDNAs for rat OBP indicate that the protein is significantly homologous to α2u-globulin and a superfamily of proteins that are believed to transport hydrophobic ligands. These data suggest that OBP transports odorants in mucus, possibly by a mechanism of facilitated diffusion. The proposed transport of odorants by OBP is analogous to the transport of molecular oxygen by hemoglobin.

AB - The odorant-binding protein (OBP) is an abundant, soluble protein of subunit molecular mass 18 000 daltons in the rat, synthesized in the lateral nasal gland, from where it is secreted into nasal mucus. The protein binds odorants of various structural classes such as pyrazines, terpenoids and aromatics. Molecular cloning and sequence analysis of several cDNAs for rat OBP indicate that the protein is significantly homologous to α2u-globulin and a superfamily of proteins that are believed to transport hydrophobic ligands. These data suggest that OBP transports odorants in mucus, possibly by a mechanism of facilitated diffusion. The proposed transport of odorants by OBP is analogous to the transport of molecular oxygen by hemoglobin.

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Odorant-binding protein: Odorant transport function in the vertebrate nasal epithelium

Abstract

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