Odorant-binding protein: Localization to nasal glands and secretions

J. Pevsner, P. B. Sklar, S. H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

An odorant-binding protein (OBP) was isolated from bovine olfactory and respiratory mucosa. We have produced polyclonal antisera to this protein and report its immunohistochemical localization to mucus-secreting glands of the olfactory and respiratory mucosa. Although OBP was originally isolated as a pyrazine binding protein, both rat and bovine OBP also bind the odorants [3H]methyldihydrojasmonate and 3,7-dimethyl-octan-1-ol as well as 2-isobutyl-3-[3H]methoxypyrazine. We detect substantial odorant-binding activity attibutable to OBP in secreted rat nasal mucus and tears but not in saliva, suggesting a role for OBP in transporting or concentrating odorants.

Original languageEnglish (US)
Pages (from-to)4942-4946
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number13
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • General

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