Oculomotor performance in obsessive-compulsive disorder

A. Y. Tien, G. D. Pearlson, S. R. Machlin, F. W. Bylsma, R. Hoehn-Saric

Research output: Contribution to journalArticlepeer-review


Objective: Neuroimaging studies have shown abnormalities of the frontal cortex and basal ganglia in persons with obsessive-compulsive disorder. Since lesions in the frontal cortex and basal ganglia areas affect performance on goal-guided saccadic eye movements, this study investigated the relation between the diagnosis of obsessive-compulsive disorder and oculomotor performance. Method: Eleven patients with the clinical diagnosis of obsessive-compulsive disorder and 14 normal subjects were assessed with respect to their performance on both visual-guided and goal-guided oculomotor tasks. Fixation performance was also measured. Results: The group with obsessive-compulsive disorder had a very significantly greater error rate and a significantly greater rate of inaccurate saccades on the goal-guided antisaccade task, whereas they were not different from the normal group in reaction time, saccadic velocity, and accuracy on the visual-guided saccade task. The distribution of error rates for the patients with obsessive- compulsive disorder was broad, with more than one-half outside the range of the normal group. Most of the abnormal findings were among male patients. Conclusions: The results support the hypothesis of a relationship between impaired performance on goal-guided saccadic eye movement tasks and the diagnosis of obsessive-compulsive disorder, but they also suggest a gender- related subgroup within the group with obsessive-compulsive disorder.

Original languageEnglish (US)
Pages (from-to)641-646
Number of pages6
JournalAmerican Journal of Psychiatry
Issue number5
StatePublished - 1992

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'Oculomotor performance in obsessive-compulsive disorder'. Together they form a unique fingerprint.

Cite this