Ocular surface reconstruction

Recent innovations, surgical candidate selection and postoperative management

Research output: Contribution to journalArticle

Abstract

Intricate homeostasis maintains the rich complexity and functionality of the ocular surface. Severe ocular surface diseases cause significant morbidities, including blindness. Ocular surface reconstruction strategies restore this homeostasis. Patients with limbal deficiency may benefit from limbal stem cell transplantation to alleviate persistent epithelial defects, maintain conjunctivalization regression and corneal avascularity, and restore vision. Amniotic membrane and other substrates function as tissue surrogates and substrates for expansion of stem cells. Maximum graft survivability necessitates aggressive and comprehensive preoperative management of inflammation, infection, microtrauma, dry eye conditions and HLA compatibility. Restoration of lacrimal gland function is important, as is implementation of aggressive immunosuppression. Future advancements in stem cell biology, tissue engineering, bioartificial microsystems or regenerative medicine will supplement the therapeutic armamentarium. The next decade will be an exciting time for corneal surgeons.

Original languageEnglish (US)
Pages (from-to)567-584
Number of pages18
JournalExpert Review of Ophthalmology
Volume3
Issue number5
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Surface reconstruction
Stem cells
Innovation
Homeostasis
Stem Cells
Cytology
Lacrimal Apparatus
Amnion
Regenerative Medicine
Eye Diseases
Microsystems
Stem Cell Transplantation
Substrates
Blindness
Tissue Engineering
Tissue engineering
Grafts
Immunosuppression
Restoration
Cell Biology

Keywords

  • Amniotic membrane
  • Limbal stem cell transplant
  • Ocular surface reconstruction
  • Patient management
  • Prosthesis

ASJC Scopus subject areas

  • Ophthalmology
  • Biomedical Engineering
  • Optometry

Cite this

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