Ocular surface reconstruction: Recent advances and future outlook

Samuel C. Yiu, Padmaja B. Thomas, Pho Nguyen

Research output: Contribution to journalReview articlepeer-review

Abstract

PURPOSE OF REVIEW: Ocular surface disorder underlies a diverse group of prevalent diseases in the United States, caused by biological aging, autoimmune conditions, trauma, or iatrogenic factors. Left untreated, these conditions can progress to vision loss or destruction of the globe itself. This review discusses the most recent and relevant clinical and experimental advances in the treatment options for ocular surface disorders. RECENT FINDINGS: Current literature suggests that recent progress in tissue bioengineering, and molecular and cellular biology research presents many potential interventional therapies for ocular surface diseases. Depending on the pathogenesis of each condition, treatment options include bioengineered amniotic membrane graft, limbal stem cell transplantation, conjunctival and extraocular tissue transplantation, multiagent immunosuppressant therapy, and bioartificial devices such as lacrimal gland microdevices and keratoprostheses, or tissue adhesives. SUMMARY: Much progress has been made in the fields of microbiology, stem-cell research, tissue engineering, and bioartificial devices for the treatment of the heterogeneous group of ocular surface disorders. Intensive efforts are underway to ensure the adaptation and accessibility of these therapeutic options to the general population.

Original languageEnglish (US)
Pages (from-to)509-514
Number of pages6
JournalCurrent opinion in ophthalmology
Volume18
Issue number6
DOIs
StatePublished - Nov 2007
Externally publishedYes

Keywords

  • Amniotic membrane graft
  • Biotissue engineering
  • Implant devices
  • Limbal stem-cell transplantation
  • Ocular surface disease
  • Regenerative medicine

ASJC Scopus subject areas

  • Ophthalmology

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