Ocular surface epithelial atypia mimicking squamous neoplasia in association with ulcerative colitis

Sally Ong, Scott D. Walter, Xi Chen, Gargi K. Vora, Melissa Daluvoy, Alan D. Proia, Prithvi Mruthyunjaya

Research output: Contribution to journalArticle

Abstract

Purpose: Inflammatory bowel disease may be associated with extraintestinal manifestations. We report a case of severe reactive epithelial atypia resembling ocular surface squamous neoplasia (OSSN) in a patient with ulcerative colitis (UC). Methods: Case report. Results: A 32-year-old woman presented with sequential, progressive keratoconjunctival lesions in the left and right eyes, and both lesions were excised. Anterior segment optical coherence tomography demonstrated features similar to OSSN, whereas histological examination revealed severe reactive epithelial atypia mimicking severe dysplasia. Shortly after treatment of the second eye, the patient was diagnosed with UC. Residual disease improved dramatically in response to systemic corticosteroids. Conclusions: Severe ocular surface epithelial atypia resembling OSSN may be seen in association with UC.

Original languageEnglish (US)
Pages (from-to)502-505
Number of pages4
JournalCornea
Volume36
Issue number4
DOIs
StatePublished - Apr 1 2017
Externally publishedYes

Keywords

  • conjunctiva
  • cornea
  • epithelial atypia
  • inflammation
  • inflammatory bowel disease
  • ocular surface
  • ocular surface squamous neoplasia
  • ulcerative colitis

ASJC Scopus subject areas

  • Ophthalmology

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  • Cite this

    Ong, S., Walter, S. D., Chen, X., Vora, G. K., Daluvoy, M., Proia, A. D., & Mruthyunjaya, P. (2017). Ocular surface epithelial atypia mimicking squamous neoplasia in association with ulcerative colitis. Cornea, 36(4), 502-505. https://doi.org/10.1097/ICO.0000000000001144