Ocular stem cell research from basic science to clinical application: A report from zhongshan ophthalmic center ocular stem cell symposium

Hong Ouyang, Jeffrey L. Goldberg, Shuyi Chen, Wei Li, Guo Tong Xu, Wei Li, Kang Zhang, Robert B. Nussenblatt, Yizhi Liu, Ting Xie, Chi Chao Chan, Donald J. Zack

Research output: Contribution to journalArticle

Abstract

Stem cells hold promise for treating a wide variety of diseases, including degenerative disorders of the eye. The eye is an ideal organ for stem cell therapy because of its relative immunological privilege, surgical accessibility, and its being a self-contained system. The eye also has many potential target diseases amenable to stem cell-based treatment, such as corneal limbal stem cell deficiency, glaucoma, age-related macular degeneration (AMD), and retinitis pigmentosa (RP). Among them, AMD and glaucoma are the two most common diseases, affecting over 200 million people worldwide. Recent results on the clinical trial of retinal pigment epithelial (RPE) cells from human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) in treating dry AMD and Stargardt’s disease in the US, Japan, England, and China have generated great excitement and hope. This marks the beginning of the ocular stem cell therapy era. The recent Zhongshan Ophthalmic Center Ocular Stem Cell Symposium discussed the potential applications of various stem cell types in stem cell-based therapies, drug discoveries and tissue engineering for treating ocular diseases.

Original languageEnglish (US)
Article number415
JournalInternational journal of molecular sciences
Volume17
Issue number3
DOIs
StatePublished - Mar 22 2016

Keywords

  • Age-related macular degeneration
  • Eye diseases
  • Glaucoma
  • Limbal stem cell deficiency
  • Regenerative medicine
  • Stem cells

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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