Ocular renin angiotensin: EM immunocytochemical localization of prorenin

Ingolf H.L. Wallow; Stephen J. Sramek; Colleen D. Bindley; Soesiawati R. Darjatmoko; Stephen J. Gange

doi:10.3109/02713689309020401

Ocular renin angiotensin: EM immunocytochemical localization of prorenin

Ingolf H.L. Wallow, Stephen J. Sramek, Colleen D. Bindley, Soesiawati R. Darjatmoko, Stephen J. Gange

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Prorenin (PR) was localized by electron microscopic (EM) immunostaming of cryo-ultramicrotomy sections of human ciliary body and correlated with light microscopic immunoskuning. Both layers of the ciliary epithelium contained the prohormone. However, density was much higher in the adjacent extracellular spaces, particularly in the vitreous cortex. This observation adds further evidence to a role of the the ciliary epithelium in the transfer, storage or synthesis of components of a putative ocular renin angiotensin system.

Original language	English (US)
Pages (from-to)	945-950
Number of pages	6
Journal	Current Eye Research
Volume	12
Issue number	10
DOIs	https://doi.org/10.3109/02713689309020401
State	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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title = "Ocular renin angiotensin: EM immunocytochemical localization of prorenin",

abstract = "Prorenin (PR) was localized by electron microscopic (EM) immunostaming of cryo-ultramicrotomy sections of human ciliary body and correlated with light microscopic immunoskuning. Both layers of the ciliary epithelium contained the prohormone. However, density was much higher in the adjacent extracellular spaces, particularly in the vitreous cortex. This observation adds further evidence to a role of the the ciliary epithelium in the transfer, storage or synthesis of components of a putative ocular renin angiotensin system.",

author = "Wallow, {Ingolf H.L.} and Sramek, {Stephen J.} and Bindley, {Colleen D.} and Darjatmoko, {Soesiawati R.} and Gange, {Stephen J.}",

note = "Funding Information: ACKNOWLEDGEMENTS Supported by National Institutes of Health research grant NIH-NEI EY-01634, by NEI training grant T-32 EY-07119 (S. Gange), by a grant from the Miller Foundation, and by an unrestricted grant from Research to Prevent Blindness, Inc. to the Department of Ophthalmology.",

year = "1993",

doi = "10.3109/02713689309020401",

language = "English (US)",

volume = "12",

pages = "945--950",

journal = "Current Eye Research",

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TY - JOUR

T1 - Ocular renin angiotensin

T2 - EM immunocytochemical localization of prorenin

AU - Wallow, Ingolf H.L.

AU - Sramek, Stephen J.

AU - Bindley, Colleen D.

AU - Darjatmoko, Soesiawati R.

AU - Gange, Stephen J.

N1 - Funding Information: ACKNOWLEDGEMENTS Supported by National Institutes of Health research grant NIH-NEI EY-01634, by NEI training grant T-32 EY-07119 (S. Gange), by a grant from the Miller Foundation, and by an unrestricted grant from Research to Prevent Blindness, Inc. to the Department of Ophthalmology.

PY - 1993

Y1 - 1993

N2 - Prorenin (PR) was localized by electron microscopic (EM) immunostaming of cryo-ultramicrotomy sections of human ciliary body and correlated with light microscopic immunoskuning. Both layers of the ciliary epithelium contained the prohormone. However, density was much higher in the adjacent extracellular spaces, particularly in the vitreous cortex. This observation adds further evidence to a role of the the ciliary epithelium in the transfer, storage or synthesis of components of a putative ocular renin angiotensin system.

AB - Prorenin (PR) was localized by electron microscopic (EM) immunostaming of cryo-ultramicrotomy sections of human ciliary body and correlated with light microscopic immunoskuning. Both layers of the ciliary epithelium contained the prohormone. However, density was much higher in the adjacent extracellular spaces, particularly in the vitreous cortex. This observation adds further evidence to a role of the the ciliary epithelium in the transfer, storage or synthesis of components of a putative ocular renin angiotensin system.

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Ocular renin angiotensin: EM immunocytochemical localization of prorenin

Abstract

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