Ocular manifestations of systemic malignancies

Sharon Solomon, Jennifer Hasenyager Smith, Joan O'Brien

Research output: Contribution to journalArticle

Abstract

Ocular manifestations of systemic malignancy are important for both the ophthalmologist and the internist to recognize because they may precede the diagnosis of cancer. This review of the current literature discusses the clinical manifestations etiology, and potential therapeutic interventions for a group of visual paraneoplastic syndromes, including carcinoma-associated retinopathy and melanoma-associated retinopathy. These conditions are characterized by elevated serum levels of autoantibodies directed against tumor antigen that cross-react with retinal proteins, resulting in rod and cone dysfunction. The clinical presentation, site of origin, frequency, and intraocular distribution of tumors metastatic to the eye are also reviewed.

Original languageEnglish (US)
Pages (from-to)447-451
Number of pages5
JournalCurrent Opinion in Ophthalmology
Volume10
Issue number6
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Eye Manifestations
Ocular Paraneoplastic Syndromes
Paraneoplastic Syndromes
Neoplasms
Vertebrate Photoreceptor Cells
Neoplasm Antigens
Autoantibodies
Carcinoma
Serum
Proteins
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ocular manifestations of systemic malignancies. / Solomon, Sharon; Hasenyager Smith, Jennifer; O'Brien, Joan.

In: Current Opinion in Ophthalmology, Vol. 10, No. 6, 1999, p. 447-451.

Research output: Contribution to journalArticle

Solomon, Sharon ; Hasenyager Smith, Jennifer ; O'Brien, Joan. / Ocular manifestations of systemic malignancies. In: Current Opinion in Ophthalmology. 1999 ; Vol. 10, No. 6. pp. 447-451.
@article{8290e1a0bf2c41709b339c0191ed1133,
title = "Ocular manifestations of systemic malignancies",
abstract = "Ocular manifestations of systemic malignancy are important for both the ophthalmologist and the internist to recognize because they may precede the diagnosis of cancer. This review of the current literature discusses the clinical manifestations etiology, and potential therapeutic interventions for a group of visual paraneoplastic syndromes, including carcinoma-associated retinopathy and melanoma-associated retinopathy. These conditions are characterized by elevated serum levels of autoantibodies directed against tumor antigen that cross-react with retinal proteins, resulting in rod and cone dysfunction. The clinical presentation, site of origin, frequency, and intraocular distribution of tumors metastatic to the eye are also reviewed.",
author = "Sharon Solomon and {Hasenyager Smith}, Jennifer and Joan O'Brien",
year = "1999",
doi = "10.1097/00055735-199912000-00013",
language = "English (US)",
volume = "10",
pages = "447--451",
journal = "Current Opinion in Ophthalmology",
issn = "1040-8738",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Ocular manifestations of systemic malignancies

AU - Solomon, Sharon

AU - Hasenyager Smith, Jennifer

AU - O'Brien, Joan

PY - 1999

Y1 - 1999

N2 - Ocular manifestations of systemic malignancy are important for both the ophthalmologist and the internist to recognize because they may precede the diagnosis of cancer. This review of the current literature discusses the clinical manifestations etiology, and potential therapeutic interventions for a group of visual paraneoplastic syndromes, including carcinoma-associated retinopathy and melanoma-associated retinopathy. These conditions are characterized by elevated serum levels of autoantibodies directed against tumor antigen that cross-react with retinal proteins, resulting in rod and cone dysfunction. The clinical presentation, site of origin, frequency, and intraocular distribution of tumors metastatic to the eye are also reviewed.

AB - Ocular manifestations of systemic malignancy are important for both the ophthalmologist and the internist to recognize because they may precede the diagnosis of cancer. This review of the current literature discusses the clinical manifestations etiology, and potential therapeutic interventions for a group of visual paraneoplastic syndromes, including carcinoma-associated retinopathy and melanoma-associated retinopathy. These conditions are characterized by elevated serum levels of autoantibodies directed against tumor antigen that cross-react with retinal proteins, resulting in rod and cone dysfunction. The clinical presentation, site of origin, frequency, and intraocular distribution of tumors metastatic to the eye are also reviewed.

UR - http://www.scopus.com/inward/record.url?scp=0032744918&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032744918&partnerID=8YFLogxK

U2 - 10.1097/00055735-199912000-00013

DO - 10.1097/00055735-199912000-00013

M3 - Article

C2 - 10662250

AN - SCOPUS:0032744918

VL - 10

SP - 447

EP - 451

JO - Current Opinion in Ophthalmology

JF - Current Opinion in Ophthalmology

SN - 1040-8738

IS - 6

ER -