TY - JOUR
T1 - Ocular manifestations of acute pandysautonomia
AU - Yee, Robert D.
AU - Trese, Michael
AU - Zee, David S.
AU - Kollarits, Carol R.
AU - Cogan, David G.
PY - 1976/6
Y1 - 1976/6
N2 - A 33-year-old white man developed premature presbyopia and anisocoria as initial manifestations of acute pandysautonomia. Nine months later signs and symptoms of generalized, severe autonomic dysfunction developed, and six years later only paralysis of pupillary reactions, presbyopia, and orthostatic hypotension were unresolved. Pharmacologic testing of the pupils demonstrated no mydriasis to cocaine 4% or hydroxy-amphetamine 1% and hypersensitivity to epinephrine 0.1%, methacholine 2.5%, and pilocarpine 0.0625%, suggesting the presence of sympathetic and parasympathetic, postganglionic blockage of autonomic innervation of the iris.
AB - A 33-year-old white man developed premature presbyopia and anisocoria as initial manifestations of acute pandysautonomia. Nine months later signs and symptoms of generalized, severe autonomic dysfunction developed, and six years later only paralysis of pupillary reactions, presbyopia, and orthostatic hypotension were unresolved. Pharmacologic testing of the pupils demonstrated no mydriasis to cocaine 4% or hydroxy-amphetamine 1% and hypersensitivity to epinephrine 0.1%, methacholine 2.5%, and pilocarpine 0.0625%, suggesting the presence of sympathetic and parasympathetic, postganglionic blockage of autonomic innervation of the iris.
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U2 - 10.1016/0002-9394(76)90356-1
DO - 10.1016/0002-9394(76)90356-1
M3 - Article
C2 - 937427
AN - SCOPUS:0017122179
SN - 0002-9394
VL - 81
SP - 740
EP - 744
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 6
ER -