Ocular manifestations of acute pandysautonomia

Robert D. Yee, Michael Trese, David S. Zee, Carol R. Kollarits, David G. Cogan

Research output: Contribution to journalArticle


A 33-year-old white man developed premature presbyopia and anisocoria as initial manifestations of acute pandysautonomia. Nine months later signs and symptoms of generalized, severe autonomic dysfunction developed, and six years later only paralysis of pupillary reactions, presbyopia, and orthostatic hypotension were unresolved. Pharmacologic testing of the pupils demonstrated no mydriasis to cocaine 4% or hydroxy-amphetamine 1% and hypersensitivity to epinephrine 0.1%, methacholine 2.5%, and pilocarpine 0.0625%, suggesting the presence of sympathetic and parasympathetic, postganglionic blockage of autonomic innervation of the iris.

Original languageEnglish (US)
Pages (from-to)740-744
Number of pages5
JournalAmerican journal of ophthalmology
Issue number6
StatePublished - Jun 1976
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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