Ocular levels of azithromycin

Khalid F. Tabbara, Soliman A. Al-Kharashi, Samir M. Al-Mansouri, Othman M. Al-Omar, Hendrik Cooper, Ahmed M. Abu El-Asrar, George Foulds

Research output: Contribution to journalArticle

Abstract

Objective: To assess azithromycin levels in human serum, aqueous humor, tear fluid, and conjunctival tissue specimens after administration of a single 1-g oral dose of azithromycin. Methods: Sixty patients undergoing cataract surgery were included in this analysis. Serum, aqueous, and tear specimens were collected 3, 6, and 12 hours and 1, 2, 3, and 4 days after azithromycin administration. Conjunctival tissue biopsy specimens were collected 1, 2, 3, 4, 6, 8, 10, 12, and 14 days after azithromycin administration. All specimens were subjected to analysis by high-performance liquid chromatography-mass spectrometry. Results: Azithromycin concentration ranges during the specified sampling times were as follows: serum, 21 to 974 ng/mL; tear, 82 to 2892 ng/mL; aqueous, 10 to 69 ng/mL; and conjunctival, 0.7 to 32 μg/g. Levels above the 90% minimal inhibitory concentration (MIC90) for Chlamydia trachomatis were detected after 4 days in all tear samples and after 14 days in all conjunctival tissue specimens following oral azithromycin administration. Conclusion: We demonstrated prolonged high levels of azithromycin in drug-targeted ocular tissue. Prolonged high concentrations of azithromycin in conjunctival tissue make this drug suitable for treatment of conjunctivitis caused by chlamydiae and other susceptible organisms.

Original languageEnglish (US)
Pages (from-to)1625-1628
Number of pages4
JournalArchives of Ophthalmology
Volume116
Issue number12
StatePublished - Dec 1998
Externally publishedYes

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Azithromycin
Tears
Serum
Conjunctivitis
Chlamydia
Aqueous Humor
Chlamydia trachomatis
Pharmaceutical Preparations
Cataract
Oral Administration
Mass Spectrometry
High Pressure Liquid Chromatography
Biopsy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Tabbara, K. F., Al-Kharashi, S. A., Al-Mansouri, S. M., Al-Omar, O. M., Cooper, H., Abu El-Asrar, A. M., & Foulds, G. (1998). Ocular levels of azithromycin. Archives of Ophthalmology, 116(12), 1625-1628.

Ocular levels of azithromycin. / Tabbara, Khalid F.; Al-Kharashi, Soliman A.; Al-Mansouri, Samir M.; Al-Omar, Othman M.; Cooper, Hendrik; Abu El-Asrar, Ahmed M.; Foulds, George.

In: Archives of Ophthalmology, Vol. 116, No. 12, 12.1998, p. 1625-1628.

Research output: Contribution to journalArticle

Tabbara, KF, Al-Kharashi, SA, Al-Mansouri, SM, Al-Omar, OM, Cooper, H, Abu El-Asrar, AM & Foulds, G 1998, 'Ocular levels of azithromycin', Archives of Ophthalmology, vol. 116, no. 12, pp. 1625-1628.
Tabbara KF, Al-Kharashi SA, Al-Mansouri SM, Al-Omar OM, Cooper H, Abu El-Asrar AM et al. Ocular levels of azithromycin. Archives of Ophthalmology. 1998 Dec;116(12):1625-1628.
Tabbara, Khalid F. ; Al-Kharashi, Soliman A. ; Al-Mansouri, Samir M. ; Al-Omar, Othman M. ; Cooper, Hendrik ; Abu El-Asrar, Ahmed M. ; Foulds, George. / Ocular levels of azithromycin. In: Archives of Ophthalmology. 1998 ; Vol. 116, No. 12. pp. 1625-1628.
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