Ocular histopathology of Norrie's disease

David J. Apple, Gerald A. Fishman, Morton F Goldberg

Research output: Contribution to journalArticle

Abstract

A white male infant who had an early onset of marked visual loss was subsequently diagnosed as having Norrie's disease. The primary ocular lesions of Norrie's disease appear to result from an arrest in the development of the embryonic sensory retina with associated persistence of the primary vitreous. There is marked hypoplasia and dysplasia of retinal elements. Retention and hyperplasia of preretinal ectodermal and mesodermal components of the primary vitreous seem to be largely responsible for the characteristic preretinal membranes, secondary hemorrhage, and total retinal detachment. Histopathologic evidence suggests that this entity is pathogenetically distinct from Coats' syndrome.

Original languageEnglish (US)
Pages (from-to)196-203
Number of pages8
JournalAmerican Journal of Ophthalmology
Volume78
Issue number2
StatePublished - 1974
Externally publishedYes

Fingerprint

Retinal Dysplasia
Retinal Detachment
Embryonic Development
Hyperplasia
Retina
Hemorrhage
Membranes
Norrie disease

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ocular histopathology of Norrie's disease. / Apple, David J.; Fishman, Gerald A.; Goldberg, Morton F.

In: American Journal of Ophthalmology, Vol. 78, No. 2, 1974, p. 196-203.

Research output: Contribution to journalArticle

Apple, DJ, Fishman, GA & Goldberg, MF 1974, 'Ocular histopathology of Norrie's disease', American Journal of Ophthalmology, vol. 78, no. 2, pp. 196-203.
Apple, David J. ; Fishman, Gerald A. ; Goldberg, Morton F. / Ocular histopathology of Norrie's disease. In: American Journal of Ophthalmology. 1974 ; Vol. 78, No. 2. pp. 196-203.
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