Ocular histopathology in Eastern equine encephalitis: A case report

Eleonora M. Lad, Sally Ong, Alan D. Proia

Research output: Contribution to journalArticle

Abstract

Purpose To describe the ophthalmic symptoms and histopathological findings in a human case of Eastern equine encephalitis (EEE). Observations The patient was a septuagenarian male whose presentation and clinical course were thought to be most consistent with viral meningoencephalitis. ELISA suggested recent infection with EEE virus. Microscopic analysis of the brain demonstrated perivascular lymphohistiocytic cuffing which was consistent with viral type encephalitis. Similarly, both eyes manifested a lymphohistiocytic infiltrate in the retina and optic nerve and a reduced number of ganglion cells. Conclusions and importance To our knowledge, this is the first report of ophthalmological and ocular pathology observations in an EEE patient. Interestingly, the inflammatory findings in the retina are reminiscent of the central nervous system effects of EEE virus. These findings are relevant given the recent epidemic of microcephaly and ophthalmic complications secondary to another arboviral virus, the Zika virus.

Original languageEnglish (US)
Pages (from-to)99-102
Number of pages4
JournalAmerican Journal of Ophthalmology Case Reports
Volume5
DOIs
StatePublished - Apr 1 2017
Externally publishedYes

Fingerprint

Eastern Equine Encephalomyelitis
Eastern equine encephalitis virus
Retina
Viral Encephalitis
Microcephaly
Meningoencephalitis
Optic Nerve
Ganglia
Central Nervous System
Cell Count
Enzyme-Linked Immunosorbent Assay
Pathology
Viruses
Brain
Infection

Keywords

  • Arbovirus
  • Eastern equine encephalitis, EEE
  • Eye
  • Pathology

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ocular histopathology in Eastern equine encephalitis : A case report. / Lad, Eleonora M.; Ong, Sally; Proia, Alan D.

In: American Journal of Ophthalmology Case Reports, Vol. 5, 01.04.2017, p. 99-102.

Research output: Contribution to journalArticle

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