Ocular fluorescein phototoxicity

B. F. Hochheimer, G. A. Lutty, S. A. D' anna

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Fluorescein angiography is one of the most commonly used diagnostic techniques in modern ophthalmology. Prior to this study, recommendations on the phototoxicity of this technique were based on light levels alone (i.e., without fluorescein present). Using a rabbit model to demonstrate retinal damage, intravenous sodium fluorescein was found to reduce the amount of blue light needed to cause a phototoxic retinal lesion almost a log unit (from 1.6 to 0.2 W/cm2). Intravenous fluorescein also reduced the threshold for light damage to irisand cornea in the rabbit. The results suggest that blue light exposure should be minimized when sodium fluorescein is present in ocular tissue.

Original languageEnglish (US)
Pages (from-to)1473-1479
Number of pages7
JournalApplied Optics
Issue number8
StatePublished - Apr 15 1987
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering


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