Ocular Copper Deposition Associated with Pulmonary Carcinoma, IgG Monoclonal Gammopathy and Hypercupremia: A Clinicopathologic Correlation

Neil F. Martin, Marilyn C. Kincaid, Walter J. Stark, Brent G. Petty, Jacques L. Surer, Lawrence W. Hirst, W. Richard Green

Research output: Contribution to journalArticlepeer-review

Abstract

Hypercupremia with central deposition of copper in Descemet's membrane and lens capsule has been reported previously in lymphoproliferative disorders in two cases. A 60-year-old white man presented with visual acuity loss and was found to have an iridescent brown corneal and lenticular discoloration. Laboratory investigation revealed hypercupremia secondary to a poorly differentiated adenocarcinoma of the lung. Presence of copper in the eye was confirmed by specific atomic absorption spectra and histochemical stains of ocular tissue. This appears to be the first report of a carcinoma with associated hypercupremia presenting initially with ocular copper deposition.

Original languageEnglish (US)
Pages (from-to)110-116
Number of pages7
JournalOphthalmology
Volume90
Issue number1
DOIs
StatePublished - 1983

Keywords

  • Descemet's membrane
  • conjunctiva
  • copper deposition
  • hypercupremia
  • lens
  • pulmonary carcinoma

ASJC Scopus subject areas

  • Ophthalmology

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