Ocular complications of HIV/AIDS in the era of HAART

Millena G. Bittencourt; Owhofasa O. Agbedia; Hong T. Liu; Rachel Annam; Yasir J. Sepah; Henry Alexander Leder; Raafay Sophie; Mohamed Ibrahim; Abeer Akhtar; Anam Akhlaq; Diana V. Do; Quan Dong Nguyen

doi:10.1586/eop.12.65

Ocular complications of HIV/AIDS in the era of HAART

Millena G. Bittencourt, Owhofasa O. Agbedia, Hong T. Liu, Rachel Annam, Yasir J. Sepah, Henry Alexander Leder, Raafay Sophie, Mohamed Ibrahim, Abeer Akhtar, Anam Akhlaq, Diana V. Do, Quan Dong Nguyen

School of Medicine

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Mortality associated with AIDS has declined after the introduction of highly active antiretroviral therapy (HAART) with fewer patients progressing to severe infections. This has affected the incidence and management of HIV complications to a great extent. The natural history, incidence, management and sequelae of a wide range of HIV-Associated retinopathies, especially cytomegalovirus retinitis, have also drastically changed. The reduction in the incidence of ocular opportunistic infections due to HAART has been accompanied by a rise in the number of new HAART-Associated syndromes such as immune recovery uveitis. Immune recovery uveitis is a HAART-dependent inflammatory response that may occur in patients with regressed cytomegalovirus retinitis and elevated CD4 count and has emerged as an important cause of ocular and visual morbidity.

Original language	English (US)
Pages (from-to)	555-564
Number of pages	10
Journal	Expert Review of Ophthalmology
Volume	7
Issue number	6
DOIs	https://doi.org/10.1586/eop.12.65
State	Published - Dec 1 2012

Keywords

AIDS
HIV-Associated retinopathies
cytomegalovirus retinitis
immune recovery uveitis
ophthalmic opportunistic infections

ASJC Scopus subject areas

Biomedical Engineering
Ophthalmology
Optometry

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10.1586/eop.12.65

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title = "Ocular complications of HIV/AIDS in the era of HAART",

abstract = "Mortality associated with AIDS has declined after the introduction of highly active antiretroviral therapy (HAART) with fewer patients progressing to severe infections. This has affected the incidence and management of HIV complications to a great extent. The natural history, incidence, management and sequelae of a wide range of HIV-Associated retinopathies, especially cytomegalovirus retinitis, have also drastically changed. The reduction in the incidence of ocular opportunistic infections due to HAART has been accompanied by a rise in the number of new HAART-Associated syndromes such as immune recovery uveitis. Immune recovery uveitis is a HAART-dependent inflammatory response that may occur in patients with regressed cytomegalovirus retinitis and elevated CD4 count and has emerged as an important cause of ocular and visual morbidity.",

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AU - Bittencourt, Millena G.

AU - Agbedia, Owhofasa O.

AU - Liu, Hong T.

AU - Annam, Rachel

AU - Sepah, Yasir J.

AU - Leder, Henry Alexander

AU - Sophie, Raafay

AU - Ibrahim, Mohamed

AU - Akhtar, Abeer

AU - Akhlaq, Anam

AU - Do, Diana V.

AU - Nguyen, Quan Dong

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Mortality associated with AIDS has declined after the introduction of highly active antiretroviral therapy (HAART) with fewer patients progressing to severe infections. This has affected the incidence and management of HIV complications to a great extent. The natural history, incidence, management and sequelae of a wide range of HIV-Associated retinopathies, especially cytomegalovirus retinitis, have also drastically changed. The reduction in the incidence of ocular opportunistic infections due to HAART has been accompanied by a rise in the number of new HAART-Associated syndromes such as immune recovery uveitis. Immune recovery uveitis is a HAART-dependent inflammatory response that may occur in patients with regressed cytomegalovirus retinitis and elevated CD4 count and has emerged as an important cause of ocular and visual morbidity.

AB - Mortality associated with AIDS has declined after the introduction of highly active antiretroviral therapy (HAART) with fewer patients progressing to severe infections. This has affected the incidence and management of HIV complications to a great extent. The natural history, incidence, management and sequelae of a wide range of HIV-Associated retinopathies, especially cytomegalovirus retinitis, have also drastically changed. The reduction in the incidence of ocular opportunistic infections due to HAART has been accompanied by a rise in the number of new HAART-Associated syndromes such as immune recovery uveitis. Immune recovery uveitis is a HAART-dependent inflammatory response that may occur in patients with regressed cytomegalovirus retinitis and elevated CD4 count and has emerged as an important cause of ocular and visual morbidity.

KW - AIDS

KW - HIV-Associated retinopathies

KW - cytomegalovirus retinitis

KW - immune recovery uveitis

KW - ophthalmic opportunistic infections

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JO - Expert Review of Ophthalmology

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ER -

Ocular complications of HIV/AIDS in the era of HAART

Abstract

Keywords

ASJC Scopus subject areas

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